Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

Stephen J. McMahon; Wendy B. Hyland; Emilie Brun; Karl T. Butterworth; Jonathan A. Coulter; Thierry Douki; David G. Hirst; Suneil Jain; Anthony P. Kavanagh; Zeljka Krpetic; Marcus H. Mendenhall; Mark F. Muir; Kevin M. Prise; Herwig Requardt; Leon Sanche; Giuseppe Schettino; Fred J. Currell; Cecile Sicard-Roselli

doi:10.1021/jp206854s

Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

Stephen J. McMahon, Wendy B. Hyland, Emilie Brun, Karl T. Butterworth, Jonathan A. Coulter, Thierry Douki, David G. Hirst, Suneil Jain, Anthony P. Kavanagh, Zeljka Krpetic, Marcus H. Mendenhall, Mark F. Muir, Kevin M. Prise, Herwig Requardt, Leon Sanche, Giuseppe Schettino, Fred J. Currell, Cecile Sicard-Roselli

Research output: Contribution to journal › Article › peer-review

Abstract

Gold nanoparticles (GNPs) are of considerable interest for use as a radiosensitizer, because of their biocompatibility and their ability to increase dose deposited because of their high mass energy absorption coefficient. Their sensitizing properties have been verified experimentally, but a discrepancy between the experimental results and theoretical predictions suggests that the sensitizing effect does not depend solely on gold’s superior absorption of energetic photons. This work presents the results of three sets of experiments that independently mapped out the energy dependence of the radiosensitizing effects of GNPs on plasmid DNA suspended in water. Incident photon energy was varied from 11.8 to 80 keV through the use of monochromatic synchrotron and broadband X-rays. These results depart significantly from the theoretical predictions in two ways:
First, the sensitization is significantly larger than would be predicted; second, it does not vary with energy as would be predicted from
energy absorption coefficients. These results clearly demonstrate that the effects of GNP-enhanced therapies cannot be predicted by
considering additional dose alone and that a greater understanding of the processes involved is necessary for the development of
future therapeutics.

Original language	English
Pages (from-to)	20160-20167
Number of pages	8
Journal	Journal of Physical Chemistry C
Volume	115
Issue number	41
DOIs	https://doi.org/10.1021/jp206854s
Publication status	Published - 20 Oct 2011

Research Beacons, Institutes and Platforms

Dalton Nuclear Institute

Access to Document

10.1021/jp206854s

Cite this

McMahon, S. J., Hyland, W. B., Brun, E., Butterworth, K. T., Coulter, J. A., Douki, T., Hirst, D. G., Jain, S., Kavanagh, A. P., Krpetic, Z., Mendenhall, M. H., Muir, M. F., Prise, K. M., Requardt, H., Sanche, L., Schettino, G., Currell, F. J., & Sicard-Roselli, C. (2011). Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA. Journal of Physical Chemistry C, 115(41), 20160-20167. https://doi.org/10.1021/jp206854s

@article{6c65c4207d194512bd5ad7ea46d7978d,

title = "Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA",

abstract = "Gold nanoparticles (GNPs) are of considerable interest for use as a radiosensitizer, because of their biocompatibility and their ability to increase dose deposited because of their high mass energy absorption coefficient. Their sensitizing properties have been verified experimentally, but a discrepancy between the experimental results and theoretical predictions suggests that the sensitizing effect does not depend solely on gold{\textquoteright}s superior absorption of energetic photons. This work presents the results of three sets of experiments that independently mapped out the energy dependence of the radiosensitizing effects of GNPs on plasmid DNA suspended in water. Incident photon energy was varied from 11.8 to 80 keV through the use of monochromatic synchrotron and broadband X-rays. These results depart significantly from the theoretical predictions in two ways:First, the sensitization is significantly larger than would be predicted; second, it does not vary with energy as would be predicted fromenergy absorption coefficients. These results clearly demonstrate that the effects of GNP-enhanced therapies cannot be predicted byconsidering additional dose alone and that a greater understanding of the processes involved is necessary for the development offuture therapeutics.",

author = "McMahon, {Stephen J.} and Hyland, {Wendy B.} and Emilie Brun and Butterworth, {Karl T.} and Coulter, {Jonathan A.} and Thierry Douki and Hirst, {David G.} and Suneil Jain and Kavanagh, {Anthony P.} and Zeljka Krpetic and Mendenhall, {Marcus H.} and Muir, {Mark F.} and Prise, {Kevin M.} and Herwig Requardt and Leon Sanche and Giuseppe Schettino and Currell, {Fred J.} and Cecile Sicard-Roselli",

year = "2011",

month = oct,

day = "20",

doi = "10.1021/jp206854s",

language = "English",

volume = "115",

pages = "20160--20167",

journal = "Journal of Physical Chemistry C",

issn = "1932-7447",

publisher = "American Chemical Society",

number = "41",

}

McMahon, SJ, Hyland, WB, Brun, E, Butterworth, KT, Coulter, JA, Douki, T, Hirst, DG, Jain, S, Kavanagh, AP, Krpetic, Z, Mendenhall, MH, Muir, MF, Prise, KM, Requardt, H, Sanche, L, Schettino, G, Currell, FJ & Sicard-Roselli, C 2011, 'Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA', Journal of Physical Chemistry C, vol. 115, no. 41, pp. 20160-20167. https://doi.org/10.1021/jp206854s

TY - JOUR

T1 - Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

AU - McMahon, Stephen J.

AU - Hyland, Wendy B.

AU - Brun, Emilie

AU - Butterworth, Karl T.

AU - Coulter, Jonathan A.

AU - Douki, Thierry

AU - Hirst, David G.

AU - Jain, Suneil

AU - Kavanagh, Anthony P.

AU - Krpetic, Zeljka

AU - Mendenhall, Marcus H.

AU - Muir, Mark F.

AU - Prise, Kevin M.

AU - Requardt, Herwig

AU - Sanche, Leon

AU - Schettino, Giuseppe

AU - Currell, Fred J.

AU - Sicard-Roselli, Cecile

PY - 2011/10/20

Y1 - 2011/10/20

N2 - Gold nanoparticles (GNPs) are of considerable interest for use as a radiosensitizer, because of their biocompatibility and their ability to increase dose deposited because of their high mass energy absorption coefficient. Their sensitizing properties have been verified experimentally, but a discrepancy between the experimental results and theoretical predictions suggests that the sensitizing effect does not depend solely on gold’s superior absorption of energetic photons. This work presents the results of three sets of experiments that independently mapped out the energy dependence of the radiosensitizing effects of GNPs on plasmid DNA suspended in water. Incident photon energy was varied from 11.8 to 80 keV through the use of monochromatic synchrotron and broadband X-rays. These results depart significantly from the theoretical predictions in two ways:First, the sensitization is significantly larger than would be predicted; second, it does not vary with energy as would be predicted fromenergy absorption coefficients. These results clearly demonstrate that the effects of GNP-enhanced therapies cannot be predicted byconsidering additional dose alone and that a greater understanding of the processes involved is necessary for the development offuture therapeutics.

AB - Gold nanoparticles (GNPs) are of considerable interest for use as a radiosensitizer, because of their biocompatibility and their ability to increase dose deposited because of their high mass energy absorption coefficient. Their sensitizing properties have been verified experimentally, but a discrepancy between the experimental results and theoretical predictions suggests that the sensitizing effect does not depend solely on gold’s superior absorption of energetic photons. This work presents the results of three sets of experiments that independently mapped out the energy dependence of the radiosensitizing effects of GNPs on plasmid DNA suspended in water. Incident photon energy was varied from 11.8 to 80 keV through the use of monochromatic synchrotron and broadband X-rays. These results depart significantly from the theoretical predictions in two ways:First, the sensitization is significantly larger than would be predicted; second, it does not vary with energy as would be predicted fromenergy absorption coefficients. These results clearly demonstrate that the effects of GNP-enhanced therapies cannot be predicted byconsidering additional dose alone and that a greater understanding of the processes involved is necessary for the development offuture therapeutics.

U2 - 10.1021/jp206854s

DO - 10.1021/jp206854s

M3 - Article

SN - 1932-7447

VL - 115

SP - 20160

EP - 20167

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

IS - 41

ER -

Energy Dependence of Gold Nanoparticle Radiosensitization in Plasmid DNA

Abstract

Research Beacons, Institutes and Platforms

Access to Document

Fingerprint

Cite this