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Abstract
Engineered variants of phenylalanine ammonia lyase from Planctomyces brasiliensis were developed through rational design efforts focusing on the aryl binding pocket of the active site, guided by structural and phylogenetic inference. Inherent problems traditionally associated with the biocatalytic hydroamination of acrylic acids, such as low conversion and poor regioselectivity with alkyl and methoxy derivatives, could be overcome. The PbPAL variants described here represent a valuable addition to the biocatalytic toolbox, allowing previously inaccessible amino acid building blocks to be obtained regio- and enantioselectively on preparative scale.
Original language | English |
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Journal | ACS Catalysis |
Volume | 8 |
Issue number | 4 |
Early online date | 7 Mar 2018 |
DOIs | |
Publication status | Published - 2018 |
Research Beacons, Institutes and Platforms
- Biotechnology
- Manchester Institute of Biotechnology
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Dive into the research topics of 'Engineered Ammonia Lyases for the Production of Challenging Electron-Rich l-Phenylalanines'. Together they form a unique fingerprint.Activities
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Manchester Science Festival 2018: Music & Mutation
Weise, N. (Co-Organiser)
27 Oct 2018Activity: Participating in or organising event(s) › Organising a conference, workshop, exhibition, performance, inquiry, course etc › Research
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