Engineering virtual cardiac tissue.

M. R. Boyett; A. V. Holden; H. Zhang

doi:10.1093/bib/2.3.233

Engineering virtual cardiac tissue.

M. R. Boyett, A. V. Holden, H. Zhang

Research output: Contribution to journal › Article › peer-review

Abstract

The kinetics of proteins involved in ion transfer, sequestration and binding in cardiac cells can be modelled to construct a model of the electrical activity of isolated cardiac cells as a system of ordinary differential equations. These cell models may be incorporated into tissue models, which, when combined with histology and anatomy, form virtual tissues. The effects of changes in specific protein expression, or changes in protein kinetics, produced by mutations or pharmacological agents, can be simulated using these tissue models and used to account for the whole organ effects of changes in specific ion-transport protein activity.

Original language	English
Pages (from-to)	233-244
Number of pages	11
Journal	Briefings in Bioinformatics
Volume	2
Issue number	3
DOIs	https://doi.org/10.1093/bib/2.3.233
Publication status	Published - Sept 2001

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AB - The kinetics of proteins involved in ion transfer, sequestration and binding in cardiac cells can be modelled to construct a model of the electrical activity of isolated cardiac cells as a system of ordinary differential equations. These cell models may be incorporated into tissue models, which, when combined with histology and anatomy, form virtual tissues. The effects of changes in specific protein expression, or changes in protein kinetics, produced by mutations or pharmacological agents, can be simulated using these tissue models and used to account for the whole organ effects of changes in specific ion-transport protein activity.

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Engineering virtual cardiac tissue.

Abstract

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