Enhanced antisense effects resulting from an improved streptolysin-O protocol for oligodeoxynucleotide delivery into human leukaemia cells

R. V. Giles; J. Grzybowski; D. G. Spiller; D. M. Tidd

Enhanced antisense effects resulting from an improved streptolysin-O protocol for oligodeoxynucleotide delivery into human leukaemia cells

R. V. Giles, J. Grzybowski, D. G. Spiller, D. M. Tidd

Research output: Contribution to journal › Article › peer-review

Abstract

An improved protocol for delivering oligodeoxynucleotides into the cytoplasm and nucleus of human cells in culture using streptolysin O is described. The new procedure permitted reduced target protein expression to result from antisense suppression of target mRNA levels.

Original language	English
Pages (from-to)	1155-1163
Number of pages	8
Journal	Nucleosides and Nucleotides
Volume	16
Issue number	7-9
Publication status	Published - 1997

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title = "Enhanced antisense effects resulting from an improved streptolysin-O protocol for oligodeoxynucleotide delivery into human leukaemia cells",

abstract = "An improved protocol for delivering oligodeoxynucleotides into the cytoplasm and nucleus of human cells in culture using streptolysin O is described. The new procedure permitted reduced target protein expression to result from antisense suppression of target mRNA levels.",

author = "Giles, {R. V.} and J. Grzybowski and Spiller, {D. G.} and Tidd, {D. M.}",

note = "XII International Round Table on Nucleosides, Nucleotides and their Biological Applications - Making Drugs Out of Nucleosides and Oligonucleotides Sep 15-19, 1996 La jolla, ca",

year = "1997",

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volume = "16",

pages = "1155--1163",

journal = "Nucleosides and Nucleotides",

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T1 - Enhanced antisense effects resulting from an improved streptolysin-O protocol for oligodeoxynucleotide delivery into human leukaemia cells

AU - Giles, R. V.

AU - Grzybowski, J.

AU - Spiller, D. G.

AU - Tidd, D. M.

N1 - XII International Round Table on Nucleosides, Nucleotides and their Biological Applications - Making Drugs Out of Nucleosides and Oligonucleotides Sep 15-19, 1996 La jolla, ca

PY - 1997

Y1 - 1997

N2 - An improved protocol for delivering oligodeoxynucleotides into the cytoplasm and nucleus of human cells in culture using streptolysin O is described. The new procedure permitted reduced target protein expression to result from antisense suppression of target mRNA levels.

AB - An improved protocol for delivering oligodeoxynucleotides into the cytoplasm and nucleus of human cells in culture using streptolysin O is described. The new procedure permitted reduced target protein expression to result from antisense suppression of target mRNA levels.

M3 - Article

SN - 0732-8311

VL - 16

SP - 1155

EP - 1163

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

IS - 7-9

ER -

Enhanced antisense effects resulting from an improved streptolysin-O protocol for oligodeoxynucleotide delivery into human leukaemia cells

Abstract

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