Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Fabrizio Simeoni; Tim Cp Somervaille

doi:10.1080/23723556.2021.2003161

Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

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Abstract

Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transducin-like enhancer protein 3) repressor complex at enhancers controlling myeloid differentiation genes.

Original language	English
Pages (from-to)	2003161
Journal	Molecular & cellular oncology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1080/23723556.2021.2003161
Publication status	Published - 2021

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10.1080/23723556.2021.2003161

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title = "Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia",

abstract = "Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transducin-like enhancer protein 3) repressor complex at enhancers controlling myeloid differentiation genes.",

author = "Fabrizio Simeoni and Somervaille, \{Tim Cp\}",

note = "{\textcopyright} 2021 Taylor \& Francis Group, LLC.",

year = "2021",

doi = "10.1080/23723556.2021.2003161",

language = "English",

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AU - Simeoni, Fabrizio

AU - Somervaille, Tim Cp

PY - 2021

Y1 - 2021

N2 - Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transducin-like enhancer protein 3) repressor complex at enhancers controlling myeloid differentiation genes.

AB - Tissue-inappropriate expression of FOXC1 (Forkhead Box C1) in acute myeloid leukemia confers a monocyte/macrophage lineage differentiation block. We discovered that FOXC1 interacts with RUNX1 (Runt-Related Transcription Factor 1) to stabilize a RUNX1, HDAC1 (Histone Deacetylase 1) and TLE3 (Transducin-like enhancer protein 3) repressor complex at enhancers controlling myeloid differentiation genes.

UR - https://www.scopus.com/pages/publications/85119694320

U2 - 10.1080/23723556.2021.2003161

DO - 10.1080/23723556.2021.2003161

M3 - Article

C2 - 35419467

SN - 2372-3556

VL - 8

SP - 2003161

JO - Molecular & cellular oncology

JF - Molecular & cellular oncology

IS - 6

ER -

Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Abstract

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