Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix

S. B. Donaldson; D. L. Buckley; J. P. O'Connor; S. E. Davidson; B. M. Carrington; A. P. Jones; C. M L West

doi:10.1038/sj.bjc.6605415

Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix

S. B. Donaldson, D. L. Buckley, J. P. O'Connor, S. E. Davidson, B. M. Carrington, A. P. Jones, C. M L West

Research output: Contribution to journal › Article › peer-review

Abstract

Background: There is a need for simple imaging parameters capable of predicting therapeutic outcome.Methods: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E F) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).Results: Tumours with high E F had a significantly poorer probability of DFS than those with low E F (P0.011).Interpretation:E F is a simple imaging biomarker that should be studied further in a multi-centre setting. © 2010 Cancer Research UK All rights reserved.

Original language	English
Pages (from-to)	23-26
Number of pages	3
Journal	British Journal of Cancer
Volume	102
Issue number	1
DOIs	https://doi.org/10.1038/sj.bjc.6605415
Publication status	Published - Jan 2010

Keywords

Cervix cancer
Dynamic contrast-enhanced MRI
Enhancing fraction
Imaging biomarkers
Radiotherapy

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix",

abstract = "Background: There is a need for simple imaging parameters capable of predicting therapeutic outcome.Methods: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E F) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).Results: Tumours with high E F had a significantly poorer probability of DFS than those with low E F (P0.011).Interpretation:E F is a simple imaging biomarker that should be studied further in a multi-centre setting. {\textcopyright} 2010 Cancer Research UK All rights reserved.",

keywords = "Cervix cancer, Dynamic contrast-enhanced MRI, Enhancing fraction, Imaging biomarkers, Radiotherapy",

author = "Donaldson, {S. B.} and Buckley, {D. L.} and O'Connor, {J. P.} and Davidson, {S. E.} and Carrington, {B. M.} and Jones, {A. P.} and West, {C. M L}",

year = "2010",

month = jan,

doi = "10.1038/sj.bjc.6605415",

language = "English",

volume = "102",

pages = "23--26",

journal = "British Journal of Cancer",

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T1 - Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix

AU - Donaldson, S. B.

AU - Buckley, D. L.

AU - O'Connor, J. P.

AU - Davidson, S. E.

AU - Carrington, B. M.

AU - Jones, A. P.

AU - West, C. M L

PY - 2010/1

Y1 - 2010/1

N2 - Background: There is a need for simple imaging parameters capable of predicting therapeutic outcome.Methods: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E F) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).Results: Tumours with high E F had a significantly poorer probability of DFS than those with low E F (P0.011).Interpretation:E F is a simple imaging biomarker that should be studied further in a multi-centre setting. © 2010 Cancer Research UK All rights reserved.

AB - Background: There is a need for simple imaging parameters capable of predicting therapeutic outcome.Methods: This retrospective study analysed 50 patients with locally advanced carcinoma of the cervix who underwent dynamic contrast-enhanced MRI before receiving potentially curative radiotherapy. The proportion of enhancing pixels (E F) in the whole-tumour volume post-contrast agent injection was calculated and assessed in relation to disease-free survival (DFS).Results: Tumours with high E F had a significantly poorer probability of DFS than those with low E F (P0.011).Interpretation:E F is a simple imaging biomarker that should be studied further in a multi-centre setting. © 2010 Cancer Research UK All rights reserved.

KW - Cervix cancer

KW - Dynamic contrast-enhanced MRI

KW - Enhancing fraction

KW - Imaging biomarkers

KW - Radiotherapy

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DO - 10.1038/sj.bjc.6605415

M3 - Article

SN - 0007-0920

VL - 102

SP - 23

EP - 26

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 1

ER -

Enhancing fraction measured using dynamic contrast-enhanced MRI predicts disease-free survival in patients with carcinoma of the cervix

Abstract

Keywords

UN SDGs

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