Envelope-Constrained Neutralization-Sensitive HIV-1 after Heterosexual Transmission

Cynthia A. Derdeyn; Julie M. Decker; Frederic Bibollet-Ruche; John L. Mokili; Mark Muldoon; Scott A. Denham; Marintha L. Heil; Francis Kasolo; Rosemary Musonda; Beatrice H. Hahn; George M. Shaw; Bette T. Korber; Susan Allen; Eric Hunter

doi:10.1126/science.1093137

Envelope-Constrained Neutralization-Sensitive HIV-1 after Heterosexual Transmission

Cynthia A. Derdeyn, Julie M. Decker, Frederic Bibollet-Ruche, John L. Mokili, Mark Muldoon, Scott A. Denham, Marintha L. Heil, Francis Kasolo, Rosemary Musonda, Beatrice H. Hahn, George M. Shaw, Bette T. Korber, Susan Allen, Eric Hunter

Research output: Contribution to journal › Article › peer-review

Abstract

Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

Original language	English
Pages (from-to)	2019-2022
Number of pages	3
Journal	Science
Volume	303
Issue number	5666
DOIs	https://doi.org/10.1126/science.1093137
Publication status	Published - 26 Mar 2004

Keywords

HIV/AIDS, HIV transmission, vaccine design

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.1093137

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title = "Envelope-Constrained Neutralization-Sensitive HIV-1 after Heterosexual Transmission",

abstract = "Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.",

keywords = "HIV/AIDS, HIV transmission, vaccine design",

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doi = "10.1126/science.1093137",

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T1 - Envelope-Constrained Neutralization-Sensitive HIV-1 after Heterosexual Transmission

AU - Derdeyn, Cynthia A.

AU - Decker, Julie M.

AU - Bibollet-Ruche, Frederic

AU - Mokili, John L.

AU - Muldoon, Mark

AU - Denham, Scott A.

AU - Heil, Marintha L.

AU - Kasolo, Francis

AU - Musonda, Rosemary

AU - Hahn, Beatrice H.

AU - Shaw, George M.

AU - Korber, Bette T.

AU - Allen, Susan

AU - Hunter, Eric

PY - 2004/3/26

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N2 - Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

AB - Heterosexual transmission accounts for the majority of human immunodeficiency virus-1 (HIV-1) infections worldwide, yet the viral properties that determine transmission fitness or outgrowth have not been elucidated. Here we show, for eight heterosexual transmission pairs, that recipient viruses were monophyletic, encoding compact, glycan-restricted envelope glycoproteins. These viruses were also uniquely sensitive to neutralization by antibody from the transmitting partner. Thus, the exposure of neutralizing epitopes, which are lost in chronic infection because of immune escape, appears to be favored in the newly infected host. This reveals characteristics of the envelope glycoprotein that influence HIV-1 transmission and may have implications for vaccine design.

KW - HIV/AIDS, HIV transmission, vaccine design

U2 - 10.1126/science.1093137

DO - 10.1126/science.1093137

M3 - Article

SN - 0036-8075

VL - 303

SP - 2019

EP - 2022

JO - Science

JF - Science

IS - 5666

ER -

Envelope-Constrained Neutralization-Sensitive HIV-1 after Heterosexual Transmission

Abstract

Keywords

UN SDGs

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