Environmental and Health Impacts of Graphene and other Two-Dimensional Materials: A Graphene Flagship Perspective

Hazel  Lin; Tina  Buerki-Thurnherr; Peter  Wick; Marco  Pelin; Aurelia  Tubaro; Fabio  Candotto Carniel; Mauro  Tretiach; Emanuel  Flahaut; Daniel  Iglesias; Ester  Vázquez; Giada  Cellot; Laura  Ballerini; Valentina  Castagnola; Fabio  Benfenati; Andrea  Armirotti; Antoine  Sallustrau; Mathilde  Keck; Frédéric  Taran; Cyrill Bussy; Sandra Vranic; Kostas Kostarelos; Mona  Connolly; José Maria  Navas; Florence  Mouchet; Laury  Gauthier; James  Baker; Blanca  Suarez-Merino; Tomi  Kanerva; Maurizio  Prato; Bengt  Fadeel; Alberto Bianco

doi:10.1021/acsnano.3c09699

Environmental and Health Impacts of Graphene and other Two-Dimensional Materials: A Graphene Flagship Perspective

Hazel Lin, Tina Buerki-Thurnherr, Peter Wick, Marco Pelin, Aurelia Tubaro, Fabio Candotto Carniel, Mauro Tretiach, Emanuel Flahaut, Daniel Iglesias, Ester Vázquez, Giada Cellot, Laura Ballerini, Valentina Castagnola, Fabio Benfenati, Andrea Armirotti, Antoine Sallustrau, Mathilde Keck, Frédéric Taran, Cyrill Bussy, Sandra VranicKostas Kostarelos, Mona Connolly, José Maria Navas, Florence Mouchet, Laury Gauthier, James Baker, Blanca Suarez-Merino, Tomi Kanerva, Maurizio Prato, Bengt Fadeel, Alberto Bianco

Research output: Contribution to journal › Review article › peer-review

Abstract

Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets of graphene in 2004 due to the unique and versatile properties of these materials. However, the increasing production and use of 2D materials necessitate a thorough evaluation of the potential impact on human health and the environment. Furthermore, harmonized test protocols are needed with which to assess the safety of 2D materials. The Graphene Flagship project (2013-2023), funded by the European Commission, addressed the identification of the possible hazard of graphene-based materials as well as emerging 2D materials including transition metal dichalcogenides, hexagonal boron nitride, and others. Additionally, so-called green chemistry approaches were explored to achieve the goal of a safe and sustainable production and use of this fascinating family of nanomaterials. The present review provides a compact survey of the findings and the lessons learned in the Graphene Flagship.

Original language	English
Journal	ACS Nano
Early online date	13 Feb 2024
DOIs	https://doi.org/10.1021/acsnano.3c09699
Publication status	E-pub ahead of print - 13 Feb 2024

Keywords

2D nanomaterials
exposure
environment
hazard
safe-by-designc
test guidelines

Research Beacons, Institutes and Platforms

Advanced materials
National Graphene Institute

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1021/acsnano.3c09699Licence: CC BY

1 Finished

Graphene Flagship Core 3
Kostarelos, K. (PI), Bussy, C. (CoI), Coope, D. (CoI) & Vranic, S. (CoI)
1/04/20 → 30/09/23
Project: Research

6 Article

Safety Assessment of Graphene‐Based Materials
Fadeel, B., Baker, J., Ballerini, L., Bussy, C., Candotto Carniel, F., Tretiach, M., Pelin, M., Buerki‐Thurnherr, T., Kanerva, T., Navas, J. M., Vázquez, E., Rodriguez Unamuno, V., Lehtonen, P., González, M., Rauscher, H., Riego Sintes, J., Kostarelos, K., Bianco, A. & Prato, M., 15 Jan 2025, (E-pub ahead of print) In: Small. e2404570.
Research output: Contribution to journal › Article › peer-review

Open Access
File
11 Downloads (Pure)
Lung Persistence, Biodegradation, and Elimination of Graphene-Based Materials are Predominantly Size-Dependent and Mediated by Alveolar Phagocytes
Loret, T., Visani de Luna, L. A., Lucherelli, M. A., Fordham, A., Lozano, N., Bianco, A., Kostarelos, K. & Bussy, C., 27 Sept 2023, In: Small. 19, 39, 17 p., 2301201.
Research output: Contribution to journal › Article › peer-review

Open Access
Pulmonary toxicity of boron nitride nanomaterials is aspect ratio dependent
Visani de Luna, L. A., Loret, T., He, Y., Legnani, M., Lin, H., Galibert, A. M., Fordham, A., Holme, S., del Rio Castillo, A. E., Bonaccorso, F., Bianco, A., Flahaut, E., Kostarelos, K. & Bussy, C., 26 Dec 2023, In: ACS Nano. 17, 24, p. 24919-24935
Research output: Contribution to journal › Article › peer-review

Open Access

Effects of lateral dimensions on the pulmonary impact of graphene-based materials
Rodrigues, A. (Author), Kostarelos, K. (Supervisor), Hussell, T. (Supervisor) & Bussy, C. (Supervisor), 1 Aug 2019
Student thesis: Phd

File
Graphene-based enrichment of the urine proteome
Crica, L. (Author), Whetton, A. (Supervisor), Freemont, T. (Supervisor) & Kostarelos, K. (Supervisor), 1 Aug 2021
Student thesis: Phd

File
Graphene Oxide Derivatives for Biomedical Applications
Jasim, D. (Author), Kostarelos, K. (Supervisor) & Bussy, C. (Supervisor), 1 Aug 2016
Student thesis: Phd

File

Cite this

Lin, H., Buerki-Thurnherr, T., Wick, P., Pelin, M., Tubaro, A., Candotto Carniel, F., Tretiach, M., Flahaut, E., Iglesias, D., Vázquez, E., Cellot, G., Ballerini, L., Castagnola, V., Benfenati, F., Armirotti, A., Sallustrau, A., Keck, M., Taran, F., Bussy, C., ... Bianco, A. (2024). Environmental and Health Impacts of Graphene and other Two-Dimensional Materials: A Graphene Flagship Perspective. ACS Nano. Advance online publication. https://doi.org/10.1021/acsnano.3c09699

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abstract = "Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets of graphene in 2004 due to the unique and versatile properties of these materials. However, the increasing production and use of 2D materials necessitate a thorough evaluation of the potential impact on human health and the environment. Furthermore, harmonized test protocols are needed with which to assess the safety of 2D materials. The Graphene Flagship project (2013-2023), funded by the European Commission, addressed the identification of the possible hazard of graphene-based materials as well as emerging 2D materials including transition metal dichalcogenides, hexagonal boron nitride, and others. Additionally, so-called green chemistry approaches were explored to achieve the goal of a safe and sustainable production and use of this fascinating family of nanomaterials. The present review provides a compact survey of the findings and the lessons learned in the Graphene Flagship.",

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Lin, H, Buerki-Thurnherr, T, Wick, P, Pelin, M, Tubaro, A, Candotto Carniel, F, Tretiach, M, Flahaut, E, Iglesias, D, Vázquez, E, Cellot, G, Ballerini, L, Castagnola, V, Benfenati, F, Armirotti, A, Sallustrau, A, Keck, M, Taran, F, Bussy, C , Vranic, S , Kostarelos, K, Connolly, M, Navas, JM, Mouchet, F, Gauthier, L, Baker, J, Suarez-Merino, B, Kanerva, T, Prato, M, Fadeel, B & Bianco, A 2024, 'Environmental and Health Impacts of Graphene and other Two-Dimensional Materials: A Graphene Flagship Perspective', ACS Nano. https://doi.org/10.1021/acsnano.3c09699

TY - JOUR

T1 - Environmental and Health Impacts of Graphene and other Two-Dimensional Materials: A Graphene Flagship Perspective

AU - Lin, Hazel

AU - Buerki-Thurnherr, Tina

AU - Wick, Peter

AU - Pelin, Marco

AU - Tubaro, Aurelia

AU - Candotto Carniel, Fabio

AU - Tretiach, Mauro

AU - Flahaut, Emanuel

AU - Iglesias, Daniel

AU - Vázquez, Ester

AU - Cellot, Giada

AU - Ballerini, Laura

AU - Castagnola, Valentina

AU - Benfenati, Fabio

AU - Armirotti, Andrea

AU - Sallustrau, Antoine

AU - Keck, Mathilde

AU - Taran, Frédéric

AU - Bussy, Cyrill

AU - Vranic, Sandra

AU - Kostarelos, Kostas

AU - Connolly, Mona

AU - Navas, José Maria

AU - Mouchet, Florence

AU - Gauthier, Laury

AU - Baker, James

AU - Suarez-Merino, Blanca

AU - Kanerva, Tomi

AU - Prato, Maurizio

AU - Fadeel, Bengt

AU - Bianco, Alberto

PY - 2024/2/13

Y1 - 2024/2/13

N2 - Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets of graphene in 2004 due to the unique and versatile properties of these materials. However, the increasing production and use of 2D materials necessitate a thorough evaluation of the potential impact on human health and the environment. Furthermore, harmonized test protocols are needed with which to assess the safety of 2D materials. The Graphene Flagship project (2013-2023), funded by the European Commission, addressed the identification of the possible hazard of graphene-based materials as well as emerging 2D materials including transition metal dichalcogenides, hexagonal boron nitride, and others. Additionally, so-called green chemistry approaches were explored to achieve the goal of a safe and sustainable production and use of this fascinating family of nanomaterials. The present review provides a compact survey of the findings and the lessons learned in the Graphene Flagship.

AB - Two-dimensional (2D) materials have attracted tremendous interest ever since the isolation of atomically thin sheets of graphene in 2004 due to the unique and versatile properties of these materials. However, the increasing production and use of 2D materials necessitate a thorough evaluation of the potential impact on human health and the environment. Furthermore, harmonized test protocols are needed with which to assess the safety of 2D materials. The Graphene Flagship project (2013-2023), funded by the European Commission, addressed the identification of the possible hazard of graphene-based materials as well as emerging 2D materials including transition metal dichalcogenides, hexagonal boron nitride, and others. Additionally, so-called green chemistry approaches were explored to achieve the goal of a safe and sustainable production and use of this fascinating family of nanomaterials. The present review provides a compact survey of the findings and the lessons learned in the Graphene Flagship.

KW - 2D nanomaterials

KW - exposure

KW - environment

KW - hazard

KW - safe-by-designc

KW - test guidelines

U2 - 10.1021/acsnano.3c09699

DO - 10.1021/acsnano.3c09699

M3 - Review article

SN - 1936-0851

JO - ACS Nano

JF - ACS Nano

ER -

Environmental and Health Impacts of Graphene and other Two-Dimensional Materials: A Graphene Flagship Perspective

Abstract

Keywords

Research Beacons, Institutes and Platforms

UN SDGs

Access to Document

Fingerprint

Projects

Graphene Flagship Core 3

Research output

Safety Assessment of Graphene‐Based Materials

Lung Persistence, Biodegradation, and Elimination of Graphene-Based Materials are Predominantly Size-Dependent and Mediated by Alveolar Phagocytes

Pulmonary toxicity of boron nitride nanomaterials is aspect ratio dependent

Student theses

Effects of lateral dimensions on the pulmonary impact of graphene-based materials

Graphene-based enrichment of the urine proteome

Graphene Oxide Derivatives for Biomedical Applications

Cite this