Abstract
Enzyme catalysis is gaining increasing importance in synthetic chemistry. Nowadays, the growing number of biocatalysts accessible by means of bioinformatics and enzyme engineering opens up an immense variety of reactions that can be performed selectively under mild conditions. Biocatalysis especially provides excellent opportunities for late‐stage modification often superior to conventional de ‐ novo ‐synthesis. Enzymes have proven to be useful for direct introduction of functional groups into complex scaffolds, as well as for rapid diversification of compound libraries. Particularly important and highly topical are enzyme‐catalysed oxyfunctionalisations, halogenations, methylations, reductions and amide bond formations due to the high prevalence of these motifs in pharmaceuticals. This review gives an overview of the strengths and limitations of enzymatic late‐stage modifications using native and engineered enzymes in synthesis while focusing on important examples in drug development.
Original language | English |
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Pages (from-to) | 16824-16855 |
Number of pages | 32 |
Journal | Angewandte Chemie International Edition |
Volume | 60 |
Issue number | 31 |
DOIs | |
Publication status | Published - 16 Jan 2021 |
Keywords
- diversification
- enzyme engineering
- late-stage functionalisation
- oxyfunctionalisation
- selectivity