Enzymatic synthesis of peptides on a solid support

Rose Haddoub, Martin Dauner, Fiona A. Stefanowicz, Valeria Barattini, Nicolas Laurent, Sabine L. Flitsch

    Research output: Contribution to journalArticlepeer-review


    We have previously shown that dipeptides can be synthesised in high yields from amino acids using protease catalysis in aqueous media, if the amino component is immobilised on porous PEGA resin (a copolymer of polyethylene glycol and polyacrylamide). Here we explore the scope of this methodology for using protected and glycosylated amino acids as well as the synthesis of longer peptides on resin and show that such a method can also be applied on non-porous surfaces, in particular on gold. © 2009 The Royal Society of Chemistry.
    Original languageEnglish
    Pages (from-to)665-670
    Number of pages5
    JournalOrganic and Biomolecular Chemistry
    Issue number4
    Publication statusPublished - 2009


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