Enzyme catalysis on solid surfaces

Nicolas Laurent; Rose Haddoub; Sabine L. Flitsch

doi:10.1016/j.tibtech.2008.03.003

Enzyme catalysis on solid surfaces

Nicolas Laurent, Rose Haddoub, Sabine L. Flitsch

Research output: Contribution to journal › Article › peer-review

Abstract

Enzyme-catalysed reactions in which substrates are bound (immobilised) to solid surfaces are becoming increasingly important in biotechnology. There is a general drive for miniaturisation and automation in chemistry and biology, and immobilisation of the reaction intermediates and substrates, for example on microarrays or nanoparticles, helps to address technical challenges in this area. In bionanotechnology, enzyme catalysis can provide highly selective and biocompatible tools for the modification of surfaces on the nano-scale. Here, we review the range of enzyme-catalysed reactions that have been successfully performed on the solid phase and discuss their application in biotechnology. © 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	328-337
Number of pages	9
Journal	Trends in Biotechnology
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/j.tibtech.2008.03.003
Publication status	Published - Jun 2008

Keywords

SELF-ASSEMBLED MONOLAYERS
PHASE PEPTIDE-SYNTHESIS
QUARTZ-CRYSTAL
MICROBALANCE
KINETIC RESOLUTION
GLYCOPEPTIDE SYNTHESIS
BIOMIMETIC
SYNTHESIS
ALPHA-CHYMOTRYPSIN
CLEAVABLE LINKERS
MASS-SPECTROMETRY
PROTEIN-KINASES

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10.1016/j.tibtech.2008.03.003

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title = "Enzyme catalysis on solid surfaces",

abstract = "Enzyme-catalysed reactions in which substrates are bound (immobilised) to solid surfaces are becoming increasingly important in biotechnology. There is a general drive for miniaturisation and automation in chemistry and biology, and immobilisation of the reaction intermediates and substrates, for example on microarrays or nanoparticles, helps to address technical challenges in this area. In bionanotechnology, enzyme catalysis can provide highly selective and biocompatible tools for the modification of surfaces on the nano-scale. Here, we review the range of enzyme-catalysed reactions that have been successfully performed on the solid phase and discuss their application in biotechnology. {\textcopyright} 2008 Elsevier Ltd. All rights reserved.",

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author = "Nicolas Laurent and Rose Haddoub and Flitsch, {Sabine L.}",

year = "2008",

month = jun,

doi = "10.1016/j.tibtech.2008.03.003",

language = "English",

volume = "26",

pages = "328--337",

journal = "Trends in Biotechnology",

issn = "0167-7799",

publisher = "Elsevier BV",

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T1 - Enzyme catalysis on solid surfaces

AU - Laurent, Nicolas

AU - Haddoub, Rose

AU - Flitsch, Sabine L.

PY - 2008/6

Y1 - 2008/6

N2 - Enzyme-catalysed reactions in which substrates are bound (immobilised) to solid surfaces are becoming increasingly important in biotechnology. There is a general drive for miniaturisation and automation in chemistry and biology, and immobilisation of the reaction intermediates and substrates, for example on microarrays or nanoparticles, helps to address technical challenges in this area. In bionanotechnology, enzyme catalysis can provide highly selective and biocompatible tools for the modification of surfaces on the nano-scale. Here, we review the range of enzyme-catalysed reactions that have been successfully performed on the solid phase and discuss their application in biotechnology. © 2008 Elsevier Ltd. All rights reserved.

AB - Enzyme-catalysed reactions in which substrates are bound (immobilised) to solid surfaces are becoming increasingly important in biotechnology. There is a general drive for miniaturisation and automation in chemistry and biology, and immobilisation of the reaction intermediates and substrates, for example on microarrays or nanoparticles, helps to address technical challenges in this area. In bionanotechnology, enzyme catalysis can provide highly selective and biocompatible tools for the modification of surfaces on the nano-scale. Here, we review the range of enzyme-catalysed reactions that have been successfully performed on the solid phase and discuss their application in biotechnology. © 2008 Elsevier Ltd. All rights reserved.

KW - SELF-ASSEMBLED MONOLAYERS

KW - PHASE PEPTIDE-SYNTHESIS

KW - QUARTZ-CRYSTAL

KW - MICROBALANCE

KW - KINETIC RESOLUTION

KW - GLYCOPEPTIDE SYNTHESIS

KW - BIOMIMETIC

KW - SYNTHESIS

KW - ALPHA-CHYMOTRYPSIN

KW - CLEAVABLE LINKERS

KW - MASS-SPECTROMETRY

KW - PROTEIN-KINASES

U2 - 10.1016/j.tibtech.2008.03.003

DO - 10.1016/j.tibtech.2008.03.003

M3 - Article

SN - 0167-7799

VL - 26

SP - 328

EP - 337

JO - Trends in Biotechnology

JF - Trends in Biotechnology

IS - 6

ER -

Enzyme catalysis on solid surfaces

Abstract

Keywords

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