Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction

Iqbal S Toor; Dominik Rückerl; Iris Mair; Rob Ainsworth; Marco Meloni; Ana-Mishel Spiroski; Cecile Benezech; Jennifer M Felton; Adrian Thomson; Andrea Caporali; Thomas Keeble; Kare H Tang; Adriano G Rossi; David E Newby; Judith E Allen; Gillian A Gray

doi:10.1016/j.jacbts.2020.05.005

Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction

Iqbal S Toor, Dominik Rückerl, Iris Mair, Rob Ainsworth, Marco Meloni, Ana-Mishel Spiroski, Cecile Benezech, Jennifer M Felton, Adrian Thomson, Andrea Caporali, Thomas Keeble, Kare H Tang, Adriano G Rossi, David E Newby, Judith E Allen, Gillian A Gray

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.

Original language	English
Pages (from-to)	665-681
Number of pages	17
Journal	JACC: Basic to Translational Science
Volume	5
Issue number	7
DOIs	https://doi.org/10.1016/j.jacbts.2020.05.005
Publication status	Published - 8 Jul 2020

Research Beacons, Institutes and Platforms

Lydia Becker Institute

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jacbts.2020.05.005

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Toor, I. S., Rückerl, D., Mair, I., Ainsworth, R., Meloni, M., Spiroski, A.-M., Benezech, C., Felton, J. M., Thomson, A., Caporali, A., Keeble, T., Tang, K. H., Rossi, A. G., Newby, D. E., Allen, J. E., & Gray, G. A. (2020). Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction. JACC: Basic to Translational Science, 5(7), 665-681. https://doi.org/10.1016/j.jacbts.2020.05.005

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title = "Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction",

abstract = "In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.",

author = "Toor, {Iqbal S} and Dominik R{\"u}ckerl and Iris Mair and Rob Ainsworth and Marco Meloni and Ana-Mishel Spiroski and Cecile Benezech and Felton, {Jennifer M} and Adrian Thomson and Andrea Caporali and Thomas Keeble and Tang, {Kare H} and Rossi, {Adriano G} and Newby, {David E} and Allen, {Judith E} and Gray, {Gillian A}",

note = "{\textcopyright} 2020 The Authors.",

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doi = "10.1016/j.jacbts.2020.05.005",

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Toor, IS, Rückerl, D , Mair, I, Ainsworth, R, Meloni, M, Spiroski, A-M, Benezech, C, Felton, JM, Thomson, A, Caporali, A, Keeble, T, Tang, KH, Rossi, AG, Newby, DE, Allen, JE & Gray, GA 2020, 'Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction', JACC: Basic to Translational Science, vol. 5, no. 7, pp. 665-681. https://doi.org/10.1016/j.jacbts.2020.05.005

TY - JOUR

T1 - Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction

AU - Toor, Iqbal S

AU - Rückerl, Dominik

AU - Mair, Iris

AU - Ainsworth, Rob

AU - Meloni, Marco

AU - Spiroski, Ana-Mishel

AU - Benezech, Cecile

AU - Felton, Jennifer M

AU - Thomson, Adrian

AU - Caporali, Andrea

AU - Keeble, Thomas

AU - Tang, Kare H

AU - Rossi, Adriano G

AU - Newby, David E

AU - Allen, Judith E

AU - Gray, Gillian A

PY - 2020/7/8

Y1 - 2020/7/8

N2 - In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.

AB - In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.

U2 - 10.1016/j.jacbts.2020.05.005

DO - 10.1016/j.jacbts.2020.05.005

M3 - Article

C2 - 32760855

SN - 2452-302X

VL - 5

SP - 665

EP - 681

JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

IS - 7

ER -

Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction

Abstract

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