Eosinophils are key regulators of perivascular adipose tissue and vascular functionality.

Sarah Withers, Ruth Forman, Selene Meza-Perez, Daniel Sorobetea, Kasia Sitnik, Thomas Hopwood, Catherine Lawrence, William W. Agace, Kathryn Else, Anthony Heagerty, Marcus Svensson-Frej, Sheena Cruickshank

Research output: Contribution to journalArticlepeer-review


Obesity impairs the relaxant capacity of adipose tissue surrounding the vasculature (PVAT) and has been implicated in resultant obesity-related hypertension and impaired glucose intolerance. Resident immune cells are thought to regulate adipocyte activity. We investigated the role of eosinophils in mediating normal PVAT function. Healthy PVAT elicits an anti-contractile effect, which was lost in mice deficient in eosinophils, mimicking the obese phenotype, and was restored upon eosinophil reconstitution. Ex vivo studies demonstrated that the loss of PVAT function was due to reduced bioavailability of adiponectin and adipocyte-derived nitric oxide, which was restored after eosinophil reconstitution. Mechanistic studies demonstrated that adiponectin and nitric oxide are released after activation of adipocyte-expressed β3 adrenoceptors by catecholamines, and identified eosinophils as a novel source of these mediators. We conclude that adipose tissue eosinophils play a key role in the regulation of normal PVAT anti-contractile function.
Original languageEnglish
Article number44571
JournalScientific Reports
Early online date17 Mar 2017
Publication statusPublished - 17 Mar 2017

Research Beacons, Institutes and Platforms

  • Dementia@Manchester
  • Lydia Becker Institute


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