Epidemiological evidence against a role for C-reactive protein causing leptin resistance

M. K. Rutter, N. Sattar, A. Tajar, T. W. O'Neill, D. M. Lee, G. Bartfai, S. Boonen, F. F. Casanueva, J. D. Finn, G. Forti, A. Giwercman, T. S. Han, I. T. Huhtaniemi, K. Kula, M. E J Lean, N. Pendleton, M. Punab, A. J. Silman, D. Vanderschueren, G. LoweS. O'Rahilly, R. W. Morris, F. C. Wu, S. G. Wannamethee

Research output: Contribution to journalArticlepeer-review


Objective: It has been suggested that elevated levels of C-reactive protein (CRP) might interfere with leptin signalling and contribute to leptin resistance. Our aim was to assess whether plasma levels of CRP influence leptin resistance in humans, and our hypothesis was that CRP levels would modify the cross-sectional relationships between leptin and measures of adiposity. Design and methods: We assessed four measures of adiposity: BMI, waist circumference, fat mass and body fat (%) in 2113 British Regional Heart Study (BRHS) men (mean (S.D.) age 69 (5) years), with replication in 760 (age 69 (6) years) European Male Ageing Study (EMAS) subjects. Results: In BRHS subjects, leptin correlated with CRP (Spearman's r=0.22, P
Original languageEnglish
Pages (from-to)101-106
Number of pages5
JournalEuropean Journal of Endocrinology
Issue number1
Publication statusPublished - Jan 2013


  • Adipose Tissue/anatomy & histology
  • Adiposity
  • Adult
  • Aged
  • Body Mass Index
  • C-Reactive Protein/ metabolism
  • Cohort Studies
  • Drug Resistance
  • Humans
  • Leptin/ blood
  • Male
  • Middle Aged
  • Waist Circumference


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