Epidemiology of bone tumours in children and young adults

Rachel Eyre, Richard G. Feltbower, Emmanuel Mubwandarikwa, Tim O B Eden, Richard J Q McNally

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Although the epidemiology of malignant bone tumours in children and young adults has been explored, no definitive causation of any specific tumour has yet been identified. We performed a literature review (1970-2008) to find all papers covering possible aetiological factors involved in the development of bone tumours in children and young adults. Several associations have been reported with some consistency: the presence of hernias and Ewing sarcoma; high fluoride exposure and osteosarcoma; and parental farming and residence on a farm, younger age at puberty and family history of cancer for all bone tumours, especially osteosarcoma. Clearly further research is needed to confirm or refute these putative risk factors. It is likely that studies of gene-environment interactions may prove to be the most fruitful of future research. © 2009 Wiley-Liss, Inc.
    Original languageEnglish
    Pages (from-to)941-952
    Number of pages11
    JournalPediatric Blood and Cancer
    Volume53
    Issue number6
    DOIs
    Publication statusPublished - 2009

    Keywords

    • Bone cancer
    • Children
    • Epidemiology
    • Ewing sarcoma
    • Osteosarcoma
    • Teenage
    • Young adult

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