Epstein-Barr virus infection in adult renal transplant recipients

M. Morton, B. Coupes, Stephen A Roberts, S. L. Johnson, P. E. Klapper, P. J. Vallely, M. L. Picton

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Abstract

Epstein-Barr virus (EBV) DNAemia in the first year posttransplantation has been studied extensively. There is a paucity of information on prevalence and sequelae of EBV infection in adult renal transplantation beyond the first year. This single-center study examines the relationship between EBV DNAemia and demographic, immunosuppressive, hematologic and infection-related parameters in 499 renal transplant recipients between 1 month and 33 years posttransplant. Participants were tested repeatedly for EBV DNAemia detection over 12 months and clinical progress followed for 3 years. Prevalence of DNAemia at recruitment increased significantly with time from transplant. In multivariate adjusted analyses, variables associated with DNAemia included EBV seronegative status at transplant (p-=-0.045), non-White ethnicity (p-=-0.014) and previous posttransplant lymphoproliferative disease (PTLD) diagnosis (p-=-0.006), while low DNAemia rates were associated with mycophenolate mofetil use (p-
Original languageEnglish
Pages (from-to)1619-1629
Number of pages11
JournalAmerican Journal of Transplantation
Volume14
Issue number7
DOIs
Publication statusPublished - 2014

Keywords

  • Epstein-Barr virus
  • immunosuppression
  • PTLD
  • renal transplantation

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