EQUAL CPA Score 2022: a tool to measure guideline adherence for chronic pulmonary aspergillosis

Rosanne Sprute, Eva Van Braeckel, Holger Flick, Martin Hoenigl, Chris Kosmidis, Ritesh Agarwal, Jesper R Davidsen, Christian B Laursen, Oliver A Cornely, Danila Seidel

Research output: Contribution to journalArticlepeer-review


BACKGROUND: Chronic pulmonary aspergillosis (CPA) can complicate underlying pulmonary diseases, and clinical management of CPA is challenging. Guidelines support clinicians but due to the complexity of the disease they can be difficult to adhere to. OBJECTIVES: To map current guideline recommendations for the clinical management of CPA into a scoring tool to facilitate and quantify guideline adherence in clinical practice. METHODS: Recommendations for diagnosis, treatment and follow-up of CPA presented in the current ESCMID/ERS/ECMM and CPAnet guidance documents were assembled and weighed on the basis of their strength of recommendation and level of evidence. RESULTS: Twenty-seven recommendations were identified, resulting in a total maximum EQUAL CPA Score of 51. For diagnostics (ScoreMax = 27), a strong emphasis on expert consultation, culture, direct microscopy, histopathology, serology and imaging was reflected in respective points, whereas molecular techniques and susceptibility testing count into the diagnostics score to a lesser extent.Ten treatment recommendations (ScoreMax = 14), including antifungal therapy, therapeutic drug monitoring and treatment duration, were identified. Surgery, where indicated, adds three points. For refractory disease or intolerance of first-line antifungal treatment, optimal second-line treatment added another two points.During follow-up (ScoreMax = 10), response assessment via imaging gave three points, while culture and serology added two points each to the ScoreMax. CONCLUSION: The EQUAL CPA Score intents to be used as a comprehensive tool for measuring guideline adherence. If adherence to current guidelines is associated with clinical outcome, this will be assessed in future studies.

Original languageEnglish
Pages (from-to)225-231
Number of pages7
JournalJournal of Antimicrobial Chemotherapy
Issue number1
Publication statusPublished - 14 Nov 2022


  • Antifungal Agents/therapeutic use
  • Chronic Disease
  • Guideline Adherence
  • Humans
  • Pulmonary Aspergillosis/diagnosis
  • Tomography, X-Ray Computed


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