ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology

K. N. Couper; W. Chen; K. M. Houston; W. Harnett; Lawrence L. Johnson

doi:10.1111/j.1365-3024.2005.00755.x

ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology

K. N. Couper, W. Chen, K. M. Houston, W. Harnett, Lawrence L. Johnson

Research output: Contribution to journal › Article › peer-review

Abstract

ES-62, a filarial nematode-derived anti-inflammatory immunomodulator, was administered to mice in an attempt to prevent pathology associated with Toxoplasma gondii infection. The nematode product was shown to elevate mitogen and T. gondii-specific IL-10 production but was unable to inhibit Th1 responses. Consequently ES-62 could not prevent Th1 generated immunopathology. © 2005 Blackwell Publishing Ltd.

Original language	English
Pages (from-to)	147-150
Number of pages	3
Journal	Parasite Immunology
Volume	27
Issue number	4
DOIs	https://doi.org/10.1111/j.1365-3024.2005.00755.x
Publication status	Published - Apr 2005

Keywords

ES-62
Immunomodulation
Toxoplasma gondii

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10.1111/j.1365-3024.2005.00755.x

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title = "ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology",

abstract = "ES-62, a filarial nematode-derived anti-inflammatory immunomodulator, was administered to mice in an attempt to prevent pathology associated with Toxoplasma gondii infection. The nematode product was shown to elevate mitogen and T. gondii-specific IL-10 production but was unable to inhibit Th1 responses. Consequently ES-62 could not prevent Th1 generated immunopathology. {\textcopyright} 2005 Blackwell Publishing Ltd.",

keywords = "ES-62, Immunomodulation, Toxoplasma gondii",

author = "Couper, {K. N.} and W. Chen and Houston, {K. M.} and W. Harnett and Johnson, {Lawrence L.}",

note = "AI-46571, NIAID NIH HHS, United StatesAI61587, NIAID NIH HHS, United States",

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AU - Couper, K. N.

AU - Chen, W.

AU - Houston, K. M.

AU - Harnett, W.

AU - Johnson, Lawrence L.

N1 - AI-46571, NIAID NIH HHS, United StatesAI61587, NIAID NIH HHS, United States

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AB - ES-62, a filarial nematode-derived anti-inflammatory immunomodulator, was administered to mice in an attempt to prevent pathology associated with Toxoplasma gondii infection. The nematode product was shown to elevate mitogen and T. gondii-specific IL-10 production but was unable to inhibit Th1 responses. Consequently ES-62 could not prevent Th1 generated immunopathology. © 2005 Blackwell Publishing Ltd.

KW - ES-62

KW - Immunomodulation

KW - Toxoplasma gondii

U2 - 10.1111/j.1365-3024.2005.00755.x

DO - 10.1111/j.1365-3024.2005.00755.x

M3 - Article

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EP - 150

JO - Parasite Immunology

JF - Parasite Immunology

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ER -

ES-62 is unable to modulate Toxoplasma gondii-driven Th1 responses and pathology

Abstract

Keywords

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