Essential language function of the right hemisphere in brain tumor patients

Alexander Thiel; Birgit Habedank; Lutz Winhuisen; Karl Herholz; Josef Kessler; Walter F. Haupt; Wolf Dieter Heiss

doi:10.1002/ana.20342

Essential language function of the right hemisphere in brain tumor patients

Alexander Thiel, Birgit Habedank, Lutz Winhuisen, Karl Herholz, Josef Kessler, Walter F. Haupt, Wolf Dieter Heiss

Research output: Contribution to journal › Article › peer-review

Abstract

Neuroimaging studies of language networks in patients with brain lesions of the left language-dominant hemisphere have shown activation in the right inferior frontal gyrus (IFG). We tested the functional relevance of right IFG activation using neuroimaging-guided repetitive transcranial magnetic stimulation (rTMS) to disturb language function over bilateral IFG in right-handed patients with brain tumors and controls. All subjects were susceptible to TMS over the left IFG. In patients, this susceptibility correlated with left-sided the degree of language lateralization to the left. Those patients with lowest dominance were also susceptible to right-sided TMS proving relevant language function of the right IFG.

Original language	English
Pages (from-to)	128-131
Number of pages	3
Journal	Annals of Neurology
Volume	57
Issue number	1
DOIs	https://doi.org/10.1002/ana.20342
Publication status	Published - Jan 2005

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abstract = "Neuroimaging studies of language networks in patients with brain lesions of the left language-dominant hemisphere have shown activation in the right inferior frontal gyrus (IFG). We tested the functional relevance of right IFG activation using neuroimaging-guided repetitive transcranial magnetic stimulation (rTMS) to disturb language function over bilateral IFG in right-handed patients with brain tumors and controls. All subjects were susceptible to TMS over the left IFG. In patients, this susceptibility correlated with left-sided the degree of language lateralization to the left. Those patients with lowest dominance were also susceptible to right-sided TMS proving relevant language function of the right IFG.",

author = "Alexander Thiel and Birgit Habedank and Lutz Winhuisen and Karl Herholz and Josef Kessler and Haupt, {Walter F.} and Heiss, {Wolf Dieter}",

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AU - Winhuisen, Lutz

AU - Herholz, Karl

AU - Kessler, Josef

AU - Haupt, Walter F.

AU - Heiss, Wolf Dieter

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AB - Neuroimaging studies of language networks in patients with brain lesions of the left language-dominant hemisphere have shown activation in the right inferior frontal gyrus (IFG). We tested the functional relevance of right IFG activation using neuroimaging-guided repetitive transcranial magnetic stimulation (rTMS) to disturb language function over bilateral IFG in right-handed patients with brain tumors and controls. All subjects were susceptible to TMS over the left IFG. In patients, this susceptibility correlated with left-sided the degree of language lateralization to the left. Those patients with lowest dominance were also susceptible to right-sided TMS proving relevant language function of the right IFG.

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EP - 131

JO - Annals of Neurology

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ER -

Essential language function of the right hemisphere in brain tumor patients

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