@article{86de6ef303924f4f8a444dd690286234,
title = "Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity",
abstract = "Toll-like receptors (TLRs) shape innate and adaptive immunity to microorganisms. The enzyme IRAK1 transduces signals from TLRs, but mechanisms for its activation and regulation remain unknown. We found here that TLR7 and TLR9 activated the isomerase Pin1, which then bound to IRAK1; this resulted in activation of IRAK1 and facilitated its release from the receptor complex to activate the transcription factor IRF7 and induce type I interferons. Consequently, Pin1-deficient cells and mice failed to mount TLR-mediated, interferon-dependent innate and adaptive immune responses. Given the critical role of aberrant activation of IRAK1 and type I interferons in various immune diseases, controlling IRAK1 activation via inhibition of Pin1 may represent a useful therapeutic approach. {\textcopyright} 2011 Nature America, Inc. All rights reserved.",
author = "Adrian Tun-Kyi and Greg Finn and Alex Greenwood and Michael Nowak and Lee, {Tae Ho} and Asara, {John M.} and Tsokos, {George C.} and Kate Fitzgerald and Elliot Israel and Xiaoxia Li and Mark Exley and Nicholson, {Linda K.} and Lu, {Kun Ping}",
note = "AG029385, NIA NIH HHS, United StatesDK066917, NIDDK NIH HHS, United StatesGM058556, NIGMS NIH HHS, United StatesR01 AG017870-06A2, NIA NIH HHS, United StatesR01 AG017870-07, NIA NIH HHS, United StatesR01 AG017870-08, NIA NIH HHS, United StatesR01 AG017870-09, NIA NIH HHS, United StatesR01 AG017870-10, NIA NIH HHS, United StatesR01 AG029385-01, NIA NIH HHS, United StatesR01 AG029385-02, NIA NIH HHS, United StatesR01 AG029385-03, NIA NIH HHS, United StatesR01 AG029385-04, NIA NIH HHS, United StatesR01 AG029385-05, NIA NIH HHS, United StatesR01 DK066917, NIDDK NIH HHS, United StatesR01 DK066917-01, NIDDK NIH HHS, United StatesR01 DK066917-02, NIDDK NIH HHS, United StatesR01 DK066917-03, NIDDK NIH HHS, United StatesR01 DK066917-04, NIDDK NIH HHS, United StatesR01 DK066917-05, NIDDK NIH HHS, United StatesR01 GM058556-09A1, NIGMS NIH HHS, United StatesR01 GM058556-10, NIGMS NIH HHS, United StatesR01 GM058556-11, NIGMS NIH HHS, United StatesR01 GM058556-12, NIGMS NIH HHS, United States",
year = "2011",
month = aug,
doi = "10.1038/ni.2069",
language = "English",
volume = "12",
pages = "733--741",
journal = "Nature Immunology",
issn = "1529-2916",
publisher = "Springer Nature",
number = "8",
}