Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection

Yajing Wang; Xiaoliang Wang; Jean François Jasmin; Wayne Bond Lau; Rong Li; Yuexin Yuan; Wei Yi; Kurt Chuprun; Michael P. Lisanti; Walter J. Koch; Erhe Gao; Xin Liang Ma

doi:10.1161/ATVBAHA.111.242164

Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection

Yajing Wang, Xiaoliang Wang, Jean François Jasmin, Wayne Bond Lau, Rong Li, Yuexin Yuan, Wei Yi, Kurt Chuprun, Michael P. Lisanti, Walter J. Koch, Erhe Gao, Xin Liang Ma

Research output: Contribution to journal › Article › peer-review

Abstract

Objective-Adiponectin (APN) system malfunction is causatively related to increased cardiovascular morbidity/mortality in diabetic patients. The aim of the current study was to investigate molecular mechanisms responsible for APN transmembrane signaling and cardioprotection. Methods and Results-Compared with wild-type mice, caveolin-3 knockout (Cav-3KO) mice exhibited modestly increased myocardial ischemia/reperfusion injury (increased infarct size, apoptosis, and poorer cardiac function recovery; P

Original language	English
Pages (from-to)	934-942
Number of pages	8
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	32
Issue number	4
DOIs	https://doi.org/10.1161/ATVBAHA.111.242164
Publication status	Published - Apr 2012

Keywords

cytokines
diabetes mellitus
reperfusion injury
signal transduction

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1161/ATVBAHA.111.242164

Cite this

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title = "Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection",

abstract = "Objective-Adiponectin (APN) system malfunction is causatively related to increased cardiovascular morbidity/mortality in diabetic patients. The aim of the current study was to investigate molecular mechanisms responsible for APN transmembrane signaling and cardioprotection. Methods and Results-Compared with wild-type mice, caveolin-3 knockout (Cav-3KO) mice exhibited modestly increased myocardial ischemia/reperfusion injury (increased infarct size, apoptosis, and poorer cardiac function recovery; P",

keywords = "cytokines, diabetes mellitus, reperfusion injury, signal transduction",

author = "Yajing Wang and Xiaoliang Wang and Jasmin, {Jean Fran{\c c}ois} and Lau, {Wayne Bond} and Rong Li and Yuexin Yuan and Wei Yi and Kurt Chuprun and Lisanti, {Michael P.} and Koch, {Walter J.} and Erhe Gao and Ma, {Xin Liang}",

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year = "2012",

month = apr,

doi = "10.1161/ATVBAHA.111.242164",

language = "English",

volume = "32",

pages = "934--942",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

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T1 - Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection

AU - Wang, Yajing

AU - Wang, Xiaoliang

AU - Jasmin, Jean François

AU - Lau, Wayne Bond

AU - Li, Rong

AU - Yuan, Yuexin

AU - Yi, Wei

AU - Chuprun, Kurt

AU - Lisanti, Michael P.

AU - Koch, Walter J.

AU - Gao, Erhe

AU - Ma, Xin Liang

N1 - HL-096686, NHLBI NIH HHS, United StatesHL-63828, NHLBI NIH HHS, United StatesR01 HL063828-08, NHLBI NIH HHS, United StatesR01 HL096686, NHLBI NIH HHS, United StatesR01 HL096686-01A1, NHLBI NIH HHS, United StatesR01 HL096686-02, NHLBI NIH HHS, United StatesR01 HL096686-03, NHLBI NIH HHS, United States

PY - 2012/4

Y1 - 2012/4

N2 - Objective-Adiponectin (APN) system malfunction is causatively related to increased cardiovascular morbidity/mortality in diabetic patients. The aim of the current study was to investigate molecular mechanisms responsible for APN transmembrane signaling and cardioprotection. Methods and Results-Compared with wild-type mice, caveolin-3 knockout (Cav-3KO) mice exhibited modestly increased myocardial ischemia/reperfusion injury (increased infarct size, apoptosis, and poorer cardiac function recovery; P

AB - Objective-Adiponectin (APN) system malfunction is causatively related to increased cardiovascular morbidity/mortality in diabetic patients. The aim of the current study was to investigate molecular mechanisms responsible for APN transmembrane signaling and cardioprotection. Methods and Results-Compared with wild-type mice, caveolin-3 knockout (Cav-3KO) mice exhibited modestly increased myocardial ischemia/reperfusion injury (increased infarct size, apoptosis, and poorer cardiac function recovery; P

KW - cytokines

KW - diabetes mellitus

KW - reperfusion injury

KW - signal transduction

U2 - 10.1161/ATVBAHA.111.242164

DO - 10.1161/ATVBAHA.111.242164

M3 - Article

C2 - 22328772

SN - 1079-5642

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JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 4

ER -

Essential role of caveolin-3 in adiponectin signalsome formation and adiponectin cardioprotection

Abstract

Keywords

UN SDGs

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