Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000.

Andrew Robert Ness; Andrea Waylen; Katrina Hurley; Mona Jeffreys; Chris Penfold; Miranda Pring; Sam Leary; Christine Allmark; Stu Toms; Susan Ring; Tim J Peters; Will Hollingworth; Helen Worthington; Chris Nutting; Sheila Fisher; Christine Wood; Martin Persson; Simon Rogers; J K Thiruchelvam; Maged Abdelkader; Shahram Anari; Hisham Mehanna; Tom Sheehan; Karen Dyker; James McCaul; Richard Benson; Simon Stewart; Charles Hall; Jim Lester; Jarrod Homer; Abdel Hamid; Alan Lamont; Lydia Fresco; Shane Lester; Geoffrey Cogill; Amy Roy; Bernie Foran; Brian Bisase; Alistair Balfour; Andrew Evans; Simon Gollins; David Conway; Sinnappa P Gunasekaran; Laura Lees; Rachel Lowe; James England; Christopher Scrase; Richard Wight; Mehmet Sen; Margret Doyle; Russell Moule; Kate Goodchild; Nick Rowell; Dawn Beaumont-Jewell; H W Loo; Petra Jankowska; Vinidh Paleri; Richard Casasola; Tom Roques; Paul Tierney; David Hwang; P Dyson; Gerard Andrade; Taran Tatla; Judith Christian; Stuart Winter; Andrew Baldwin; Joe Davies; Emma King; Debi Barnes; Costas Repanos; Dae Kim; Stuart Richards; Nicola Dallas; Ken McAllister; Sandeep Berry; Naomi Cole; Laura Moss; Nachi Palaniappan; Mererid Evans; Christopher Nutting; Muthu Siva; Churunal Hari; Katie Wood; Richard Simcock; John Waldron; Nicholas Hyde; Imtiaz Ahmed; Daljit Gahir; James O'Hara; Ruth Carr; Martin Forster; Steve Thomas; Lynda Wagstaff; Joseph Mano; Caroline Brammer; Jayne Tyler; Andrew Coatesworth

doi:10.1186/1471-2407-14-973

Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000.

Andrew Robert Ness, Andrea Waylen, Katrina Hurley, Mona Jeffreys, Chris Penfold, Miranda Pring, Sam Leary, Christine Allmark, Stu Toms, Susan Ring, Tim J Peters, Will Hollingworth, Helen Worthington, Chris Nutting, Sheila Fisher, Christine Wood (Collaborator), Martin Persson (Collaborator), Simon Rogers (Collaborator), J K Thiruchelvam (Collaborator), Maged Abdelkader (Collaborator)Shahram Anari (Collaborator), Hisham Mehanna (Collaborator), Tom Sheehan (Collaborator), Karen Dyker (Collaborator), James McCaul (Collaborator), Richard Benson (Collaborator), Simon Stewart (Collaborator), Charles Hall (Collaborator), Jim Lester (Collaborator), Jarrod Homer (Collaborator), Abdel Hamid (Collaborator), Alan Lamont (Collaborator), Lydia Fresco (Collaborator), Shane Lester (Collaborator), Geoffrey Cogill (Collaborator), Amy Roy (Collaborator), Bernie Foran (Collaborator), Brian Bisase (Collaborator), Alistair Balfour (Collaborator), Andrew Evans (Collaborator), Simon Gollins (Collaborator), David Conway (Collaborator), Sinnappa P Gunasekaran (Collaborator), Laura Lees (Collaborator), Rachel Lowe (Collaborator), James England (Collaborator), Christopher Scrase (Collaborator), Richard Wight (Collaborator), Mehmet Sen (Collaborator), Margret Doyle (Collaborator), Russell Moule (Collaborator), Kate Goodchild (Collaborator), Nick Rowell (Collaborator), Dawn Beaumont-Jewell (Collaborator), H W Loo (Collaborator), Petra Jankowska (Collaborator), Vinidh Paleri (Collaborator), Richard Casasola (Collaborator), Tom Roques (Collaborator), Paul Tierney (Collaborator), David Hwang (Collaborator), P Dyson (Collaborator), Gerard Andrade (Collaborator), Taran Tatla (Collaborator), Judith Christian (Collaborator), Stuart Winter (Collaborator), Andrew Baldwin (Collaborator), Joe Davies (Collaborator), Emma King (Collaborator), Debi Barnes (Collaborator), Costas Repanos (Collaborator), Dae Kim (Collaborator), Stuart Richards (Collaborator), Nicola Dallas (Collaborator), Ken McAllister (Collaborator), Sandeep Berry (Collaborator), Naomi Cole (Collaborator), Laura Moss (Collaborator), Nachi Palaniappan (Collaborator), Mererid Evans (Collaborator), Christopher Nutting (Collaborator), Muthu Siva (Collaborator), Churunal Hari (Collaborator), Katie Wood (Collaborator), Richard Simcock (Collaborator), John Waldron (Collaborator), Nicholas Hyde (Collaborator), Imtiaz Ahmed (Collaborator), Daljit Gahir (Collaborator), James O'Hara (Collaborator), Ruth Carr (Collaborator), Martin Forster (Collaborator), Steve Thomas (Collaborator), Lynda Wagstaff (Collaborator), Joseph Mano (Collaborator), Caroline Brammer (Collaborator), Jayne Tyler (Collaborator), Andrew Coatesworth (Collaborator)

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors. METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires. DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research.

Original language	English
Journal	BMC Cancer
Volume	14
DOIs	https://doi.org/10.1186/1471-2407-14-973
Publication status	Published - 2014

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10.1186/1471-2407-14-973

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Ness, A. R., Waylen, A., Hurley, K., Jeffreys, M., Penfold, C., Pring, M., Leary, S., Allmark, C., Toms, S., Ring, S., Peters, T. J., Hollingworth, W., Worthington, H., Nutting, C., Fisher, S., Wood, C., Persson, M., Rogers, S., Thiruchelvam, J. K., ... Coatesworth, A. (2014). Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000. BMC Cancer, 14. https://doi.org/10.1186/1471-2407-14-973

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title = "Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000.",

abstract = "BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors. METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires. DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research.",

author = "Ness, {Andrew Robert} and Andrea Waylen and Katrina Hurley and Mona Jeffreys and Chris Penfold and Miranda Pring and Sam Leary and Christine Allmark and Stu Toms and Susan Ring and Peters, {Tim J} and Will Hollingworth and Helen Worthington and Chris Nutting and Sheila Fisher and Christine Wood and Martin Persson and Simon Rogers and Thiruchelvam, {J K} and Maged Abdelkader and Shahram Anari and Hisham Mehanna and Tom Sheehan and Karen Dyker and James McCaul and Richard Benson and Simon Stewart and Charles Hall and Jim Lester and Jarrod Homer and Abdel Hamid and Alan Lamont and Lydia Fresco and Shane Lester and Geoffrey Cogill and Amy Roy and Bernie Foran and Brian Bisase and Alistair Balfour and Andrew Evans and Simon Gollins and David Conway and Gunasekaran, {Sinnappa P} and Laura Lees and Rachel Lowe and James England and Christopher Scrase and Richard Wight and Mehmet Sen and Margret Doyle and Russell Moule and Kate Goodchild and Nick Rowell and Dawn Beaumont-Jewell and Loo, {H W} and Petra Jankowska and Vinidh Paleri and Richard Casasola and Tom Roques and Paul Tierney and David Hwang and P Dyson and Gerard Andrade and Taran Tatla and Judith Christian and Stuart Winter and Andrew Baldwin and Joe Davies and Emma King and Debi Barnes and Costas Repanos and Dae Kim and Stuart Richards and Nicola Dallas and Ken McAllister and Sandeep Berry and Naomi Cole and Laura Moss and Nachi Palaniappan and Mererid Evans and Christopher Nutting and Muthu Siva and Churunal Hari and Katie Wood and Richard Simcock and John Waldron and Nicholas Hyde and Imtiaz Ahmed and Daljit Gahir and James O'Hara and Ruth Carr and Martin Forster and Steve Thomas and Lynda Wagstaff and Joseph Mano and Caroline Brammer and Jayne Tyler and Andrew Coatesworth",

year = "2014",

doi = "10.1186/1471-2407-14-973",

language = "English",

volume = "14",

journal = "BMC Cancer",

issn = "1471-2407",

publisher = "Springer Nature",

}

Ness, AR, Waylen, A, Hurley, K, Jeffreys, M, Penfold, C, Pring, M, Leary, S, Allmark, C, Toms, S, Ring, S, Peters, TJ, Hollingworth, W, Worthington, H, Nutting, C, Fisher, S, Wood, C, Persson, M, Rogers, S, Thiruchelvam, JK, Abdelkader, M, Anari, S, Mehanna, H, Sheehan, T, Dyker, K, McCaul, J, Benson, R, Stewart, S, Hall, C, Lester, J, Homer, J, Hamid, A, Lamont, A, Fresco, L, Lester, S, Cogill, G, Roy, A, Foran, B, Bisase, B, Balfour, A, Evans, A, Gollins, S, Conway, D, Gunasekaran, SP, Lees, L, Lowe, R, England, J, Scrase, C, Wight, R, Sen, M, Doyle, M, Moule, R, Goodchild, K, Rowell, N, Beaumont-Jewell, D, Loo, HW, Jankowska, P, Paleri, V, Casasola, R, Roques, T, Tierney, P, Hwang, D, Dyson, P, Andrade, G, Tatla, T, Christian, J, Winter, S, Baldwin, A, Davies, J, King, E, Barnes, D, Repanos, C, Kim, D, Richards, S, Dallas, N, McAllister, K, Berry, S, Cole, N, Moss, L, Palaniappan, N, Evans, M, Nutting, C, Siva, M, Hari, C, Wood, K, Simcock, R, Waldron, J, Hyde, N, Ahmed, I, Gahir, D, O'Hara, J, Carr, R, Forster, M, Thomas, S, Wagstaff, L, Mano, J, Brammer, C, Tyler, J & Coatesworth, A 2014, 'Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000.', BMC Cancer, vol. 14. https://doi.org/10.1186/1471-2407-14-973

TY - JOUR

T1 - Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000.

AU - Ness, Andrew Robert

AU - Waylen, Andrea

AU - Hurley, Katrina

AU - Jeffreys, Mona

AU - Penfold, Chris

AU - Pring, Miranda

AU - Leary, Sam

AU - Allmark, Christine

AU - Toms, Stu

AU - Ring, Susan

AU - Peters, Tim J

AU - Hollingworth, Will

AU - Worthington, Helen

AU - Nutting, Chris

AU - Fisher, Sheila

A2 - Wood, Christine

A2 - Persson, Martin

A2 - Rogers, Simon

A2 - Thiruchelvam, J K

A2 - Abdelkader, Maged

A2 - Anari, Shahram

A2 - Mehanna, Hisham

A2 - Sheehan, Tom

A2 - Dyker, Karen

A2 - McCaul, James

A2 - Benson, Richard

A2 - Stewart, Simon

A2 - Hall, Charles

A2 - Lester, Jim

A2 - Homer, Jarrod

A2 - Hamid, Abdel

A2 - Lamont, Alan

A2 - Fresco, Lydia

A2 - Lester, Shane

A2 - Cogill, Geoffrey

A2 - Roy, Amy

A2 - Foran, Bernie

A2 - Bisase, Brian

A2 - Balfour, Alistair

A2 - Evans, Andrew

A2 - Gollins, Simon

A2 - Conway, David

A2 - Gunasekaran, Sinnappa P

A2 - Lees, Laura

A2 - Lowe, Rachel

A2 - England, James

A2 - Scrase, Christopher

A2 - Wight, Richard

A2 - Sen, Mehmet

A2 - Doyle, Margret

A2 - Moule, Russell

A2 - Goodchild, Kate

A2 - Rowell, Nick

A2 - Beaumont-Jewell, Dawn

A2 - Loo, H W

A2 - Jankowska, Petra

A2 - Paleri, Vinidh

A2 - Casasola, Richard

A2 - Roques, Tom

A2 - Tierney, Paul

A2 - Hwang, David

A2 - Dyson, P

A2 - Andrade, Gerard

A2 - Tatla, Taran

A2 - Christian, Judith

A2 - Winter, Stuart

A2 - Baldwin, Andrew

A2 - Davies, Joe

A2 - King, Emma

A2 - Barnes, Debi

A2 - Repanos, Costas

A2 - Kim, Dae

A2 - Richards, Stuart

A2 - Dallas, Nicola

A2 - McAllister, Ken

A2 - Berry, Sandeep

A2 - Cole, Naomi

A2 - Moss, Laura

A2 - Palaniappan, Nachi

A2 - Evans, Mererid

A2 - Nutting, Christopher

A2 - Siva, Muthu

A2 - Hari, Churunal

A2 - Wood, Katie

A2 - Simcock, Richard

A2 - Waldron, John

A2 - Hyde, Nicholas

A2 - Ahmed, Imtiaz

A2 - Gahir, Daljit

A2 - O'Hara, James

A2 - Carr, Ruth

A2 - Forster, Martin

A2 - Thomas, Steve

A2 - Wagstaff, Lynda

A2 - Mano, Joseph

A2 - Brammer, Caroline

A2 - Tyler, Jayne

A2 - Coatesworth, Andrew

PY - 2014

Y1 - 2014

N2 - BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors. METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires. DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research.

AB - BACKGROUND: Head and neck cancer is an important cause of ill health. Survival appears to be improving but the reasons for this are unclear. They could include evolving aetiology, modifications in care, improvements in treatment or changes in lifestyle behaviour. Observational studies are required to explore survival trends and identify outcome predictors. METHODS: We are identifying people with a new diagnosis of head and neck cancer. We obtain consent that includes agreement to collect longitudinal data, store samples and record linkage. Prior to treatment we give participants three questionnaires on health and lifestyle, quality of life and sexual history. We collect blood and saliva samples, complete a clinical data capture form and request a formalin fixed tissue sample. At four and twelve months we complete further data capture forms and send participants further quality of life questionnaires. DISCUSSION: This large clinical cohort of people with head and neck cancer brings together clinical data, patient-reported outcomes and biological samples in a single co-ordinated resource for translational and prognostic research.

U2 - 10.1186/1471-2407-14-973

DO - 10.1186/1471-2407-14-973

M3 - Article

C2 - 25519023

SN - 1471-2407

VL - 14

JO - BMC Cancer

JF - BMC Cancer

ER -

Establishing a large prospective clinical cohort in people with head and neck cancer as a biomedical resource: head and neck 5000.

Abstract

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