European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95)

Leon Poller; M. Keown; N. Chauhan; A. M H P Van Den Besselaar; A. Tripodi; C. Shiach; J. Jespersen

doi:10.1136/jcp.2004.019810

European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95)

Leon Poller, M. Keown, N. Chauhan, A. M H P Van Den Besselaar, A. Tripodi, C. Shiach, J. Jespersen

Research output: Contribution to journal › Article › peer-review

Abstract

A 10 centre calibration was performed after six years to determine the international sensitivity index (ISI) of rTF/95 relative to RBT/90, and to assess any international normalised ratio (INR) bias compared with the original multicentre calibration. After exclusion of one outlying centre, the follow up calibration gave a mean ISI for rTF/95 of 0.99, which although a small difference, is significantly greater than the mean ISI of 0.94 obtained previously. The change in ISI for international reference preparation (IRP) rTF/95 relative to RBT/90 would lead to a slight bias in INR for human compared with rabbit thromboplastins. At a theoretical INR of 3.0, the INR bias is 6.0%, and this is below the accepted 10% level of clinical relevance. Ongoing stability monitoring of World Health Organisation thromboplastin IRP is advised.

Original language	English
Pages (from-to)	667-669
Number of pages	2
Journal	Journal of Clinical Pathology
Volume	58
Issue number	6
DOIs	https://doi.org/10.1136/jcp.2004.019810
Publication status	Published - Jun 2005

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Poller, L., Keown, M., Chauhan, N., Van Den Besselaar, A. M. H. P., Tripodi, A., Shiach, C., & Jespersen, J. (2005). European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95). Journal of Clinical Pathology, 58(6), 667-669. https://doi.org/10.1136/jcp.2004.019810

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title = "European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95)",

abstract = "A 10 centre calibration was performed after six years to determine the international sensitivity index (ISI) of rTF/95 relative to RBT/90, and to assess any international normalised ratio (INR) bias compared with the original multicentre calibration. After exclusion of one outlying centre, the follow up calibration gave a mean ISI for rTF/95 of 0.99, which although a small difference, is significantly greater than the mean ISI of 0.94 obtained previously. The change in ISI for international reference preparation (IRP) rTF/95 relative to RBT/90 would lead to a slight bias in INR for human compared with rabbit thromboplastins. At a theoretical INR of 3.0, the INR bias is 6.0%, and this is below the accepted 10% level of clinical relevance. Ongoing stability monitoring of World Health Organisation thromboplastin IRP is advised.",

author = "Leon Poller and M. Keown and N. Chauhan and {Van Den Besselaar}, {A. M H P} and A. Tripodi and C. Shiach and J. Jespersen",

year = "2005",

month = jun,

doi = "10.1136/jcp.2004.019810",

language = "English",

volume = "58",

pages = "667--669",

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Poller, L, Keown, M, Chauhan, N, Van Den Besselaar, AMHP, Tripodi, A, Shiach, C & Jespersen, J 2005, 'European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95)', Journal of Clinical Pathology, vol. 58, no. 6, pp. 667-669. https://doi.org/10.1136/jcp.2004.019810

TY - JOUR

T1 - European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95)

AU - Poller, Leon

AU - Keown, M.

AU - Chauhan, N.

AU - Van Den Besselaar, A. M H P

AU - Tripodi, A.

AU - Shiach, C.

AU - Jespersen, J.

PY - 2005/6

Y1 - 2005/6

N2 - A 10 centre calibration was performed after six years to determine the international sensitivity index (ISI) of rTF/95 relative to RBT/90, and to assess any international normalised ratio (INR) bias compared with the original multicentre calibration. After exclusion of one outlying centre, the follow up calibration gave a mean ISI for rTF/95 of 0.99, which although a small difference, is significantly greater than the mean ISI of 0.94 obtained previously. The change in ISI for international reference preparation (IRP) rTF/95 relative to RBT/90 would lead to a slight bias in INR for human compared with rabbit thromboplastins. At a theoretical INR of 3.0, the INR bias is 6.0%, and this is below the accepted 10% level of clinical relevance. Ongoing stability monitoring of World Health Organisation thromboplastin IRP is advised.

AB - A 10 centre calibration was performed after six years to determine the international sensitivity index (ISI) of rTF/95 relative to RBT/90, and to assess any international normalised ratio (INR) bias compared with the original multicentre calibration. After exclusion of one outlying centre, the follow up calibration gave a mean ISI for rTF/95 of 0.99, which although a small difference, is significantly greater than the mean ISI of 0.94 obtained previously. The change in ISI for international reference preparation (IRP) rTF/95 relative to RBT/90 would lead to a slight bias in INR for human compared with rabbit thromboplastins. At a theoretical INR of 3.0, the INR bias is 6.0%, and this is below the accepted 10% level of clinical relevance. Ongoing stability monitoring of World Health Organisation thromboplastin IRP is advised.

U2 - 10.1136/jcp.2004.019810

DO - 10.1136/jcp.2004.019810

M3 - Article

SN - 1472-4146

VL - 58

SP - 667

EP - 669

JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

IS - 6

ER -

European Concerted Action on Anticoagulation. A multicentre calibration study of WHO international reference preparations for thromboplastin, rabbit (RBT/90) and human (rTF/95)

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