European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Weang-Kee Ho; Min-Min Tan; Nasim Mavaddat; Mei-Chee Tai; Shivaani Mariapun; Jingmei Li; Peh-Joo Ho; Joe Dennis; Jonathan P Tyrer; Manjeet K Bolla; Kyriaki Michailidou; Qin Wang; Daehee Kang; Ji-Yeob Choi; Suniza Jamaris; Xiao-Ou Shu; Sook-Yee Yoon; Sue K Park; Sung-Won Kim; Chen-Yang Shen; Jyh-Cherng Yu; Ern Yu Tan; Patrick Mun Yew Chan; Kenneth Muir; Artitaya Lophatananon; Anna H Wu; Daniel O Stram; Keitaro Matsuo; Hidemi Ito; Ching Wan Chan; Joanne Ngeow; Wei Sean Yong; Swee Ho Lim; Geok Hoon Lim; Ava Kwong; Tsun L Chan; Su Ming Tan; Jaime Seah; Esther M John; Allison W Kurian; Woon-Puay Koh; Chiea Chuen Khor; Motoki Iwasaki; Taiki Yamaji; Kiak Mien Veronique Tan; Kiat Tee Benita Tan; John J Spinelli; Kristan J Aronson; Siti Norhidayu Hasan; Kartini Rahmat; Anushya Vijayananthan; Xueling Sim; Paul D P Pharoah; Wei Zheng; Alison M Dunning; Jacques Simard; Rob Martinus van Dam; Cheng-Har Yip; Nur Aishah Mohd Taib; Mikael Hartman; Douglas F Easton; Soo-Hwang Teo; Antonis C Antoniou

doi:10.1038/s41467-020-17680-w

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Weang-Kee Ho, Min-Min Tan, Nasim Mavaddat, Mei-Chee Tai, Shivaani Mariapun, Jingmei Li, Peh-Joo Ho, Joe Dennis, Jonathan P Tyrer, Manjeet K Bolla, Kyriaki Michailidou, Qin Wang, Daehee Kang, Ji-Yeob Choi, Suniza Jamaris, Xiao-Ou Shu, Sook-Yee Yoon, Sue K Park, Sung-Won Kim, Chen-Yang ShenJyh-Cherng Yu, Ern Yu Tan, Patrick Mun Yew Chan, Kenneth Muir, Artitaya Lophatananon, Anna H Wu, Daniel O Stram, Keitaro Matsuo, Hidemi Ito, Ching Wan Chan, Joanne Ngeow, Wei Sean Yong, Swee Ho Lim, Geok Hoon Lim, Ava Kwong, Tsun L Chan, Su Ming Tan, Jaime Seah, Esther M John, Allison W Kurian, Woon-Puay Koh, Chiea Chuen Khor, Motoki Iwasaki, Taiki Yamaji, Kiak Mien Veronique Tan, Kiat Tee Benita Tan, John J Spinelli, Kristan J Aronson, Siti Norhidayu Hasan, Kartini Rahmat, Anushya Vijayananthan, Xueling Sim, Paul D P Pharoah, Wei Zheng, Alison M Dunning, Jacques Simard, Rob Martinus van Dam, Cheng-Har Yip, Nur Aishah Mohd Taib, Mikael Hartman, Douglas F Easton, Soo-Hwang Teo, Antonis C Antoniou

Division of Population Health, Health Services Research & Primary Care (L5)

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Abstract

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

Original language	English
Pages (from-to)	3833
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-17680-w
Publication status	Published - 31 Jul 2020

Keywords

Adult
Aged
Asia/epidemiology
Breast Neoplasms/diagnosis
Case-Control Studies
Europe/epidemiology
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Middle Aged
Multifactorial Inheritance
Odds Ratio
Polymorphism, Single Nucleotide
Prognosis
Risk

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-020-17680-wLicence: CC BY

s41467-020-17680-wFinal published version, 1.31 MBLicence: CC BY

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Ho, W.-K., Tan, M.-M., Mavaddat, N., Tai, M.-C., Mariapun, S., Li, J., Ho, P.-J., Dennis, J., Tyrer, J. P., Bolla, M. K., Michailidou, K., Wang, Q., Kang, D., Choi, J.-Y., Jamaris, S., Shu, X.-O., Yoon, S.-Y., Park, S. K., Kim, S.-W., ... Antoniou, A. C. (2020). European polygenic risk score for prediction of breast cancer shows similar performance in Asian women. Nature Communications, 11(1), 3833. https://doi.org/10.1038/s41467-020-17680-w

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title = "European polygenic risk score for prediction of breast cancer shows similar performance in Asian women",

abstract = "Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.",

keywords = "Adult, Aged, Asia/epidemiology, Breast Neoplasms/diagnosis, Case-Control Studies, Europe/epidemiology, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Middle Aged, Multifactorial Inheritance, Odds Ratio, Polymorphism, Single Nucleotide, Prognosis, Risk",

author = "Weang-Kee Ho and Min-Min Tan and Nasim Mavaddat and Mei-Chee Tai and Shivaani Mariapun and Jingmei Li and Peh-Joo Ho and Joe Dennis and Tyrer, {Jonathan P} and Bolla, {Manjeet K} and Kyriaki Michailidou and Qin Wang and Daehee Kang and Ji-Yeob Choi and Suniza Jamaris and Xiao-Ou Shu and Sook-Yee Yoon and Park, {Sue K} and Sung-Won Kim and Chen-Yang Shen and Jyh-Cherng Yu and Tan, {Ern Yu} and Chan, {Patrick Mun Yew} and Kenneth Muir and Artitaya Lophatananon and Wu, {Anna H} and Stram, {Daniel O} and Keitaro Matsuo and Hidemi Ito and Chan, {Ching Wan} and Joanne Ngeow and Yong, {Wei Sean} and Lim, {Swee Ho} and Lim, {Geok Hoon} and Ava Kwong and Chan, {Tsun L} and Tan, {Su Ming} and Jaime Seah and John, {Esther M} and Kurian, {Allison W} and Woon-Puay Koh and Khor, {Chiea Chuen} and Motoki Iwasaki and Taiki Yamaji and Tan, {Kiak Mien Veronique} and Tan, {Kiat Tee Benita} and Spinelli, {John J} and Aronson, {Kristan J} and Hasan, {Siti Norhidayu} and Kartini Rahmat and Anushya Vijayananthan and Xueling Sim and Pharoah, {Paul D P} and Wei Zheng and Dunning, {Alison M} and Jacques Simard and {van Dam}, {Rob Martinus} and Cheng-Har Yip and Taib, {Nur Aishah Mohd} and Mikael Hartman and Easton, {Douglas F} and Soo-Hwang Teo and Antoniou, {Antonis C}",

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doi = "10.1038/s41467-020-17680-w",

language = "English",

volume = "11",

pages = "3833",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

number = "1",

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Ho, W-K, Tan, M-M, Mavaddat, N, Tai, M-C, Mariapun, S, Li, J, Ho, P-J, Dennis, J, Tyrer, JP, Bolla, MK, Michailidou, K, Wang, Q, Kang, D, Choi, J-Y, Jamaris, S, Shu, X-O, Yoon, S-Y, Park, SK, Kim, S-W, Shen, C-Y, Yu, J-C, Tan, EY, Chan, PMY, Muir, K , Lophatananon, A, Wu, AH, Stram, DO, Matsuo, K, Ito, H, Chan, CW, Ngeow, J, Yong, WS, Lim, SH, Lim, GH, Kwong, A, Chan, TL, Tan, SM, Seah, J, John, EM, Kurian, AW, Koh, W-P, Khor, CC, Iwasaki, M, Yamaji, T, Tan, KMV, Tan, KTB, Spinelli, JJ, Aronson, KJ, Hasan, SN, Rahmat, K, Vijayananthan, A, Sim, X, Pharoah, PDP, Zheng, W, Dunning, AM, Simard, J, van Dam, RM, Yip, C-H, Taib, NAM, Hartman, M, Easton, DF, Teo, S-H & Antoniou, AC 2020, 'European polygenic risk score for prediction of breast cancer shows similar performance in Asian women', Nature Communications, vol. 11, no. 1, pp. 3833. https://doi.org/10.1038/s41467-020-17680-w

TY - JOUR

T1 - European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

AU - Ho, Weang-Kee

AU - Tan, Min-Min

AU - Mavaddat, Nasim

AU - Tai, Mei-Chee

AU - Mariapun, Shivaani

AU - Li, Jingmei

AU - Ho, Peh-Joo

AU - Dennis, Joe

AU - Tyrer, Jonathan P

AU - Bolla, Manjeet K

AU - Michailidou, Kyriaki

AU - Wang, Qin

AU - Kang, Daehee

AU - Choi, Ji-Yeob

AU - Jamaris, Suniza

AU - Shu, Xiao-Ou

AU - Yoon, Sook-Yee

AU - Park, Sue K

AU - Kim, Sung-Won

AU - Shen, Chen-Yang

AU - Yu, Jyh-Cherng

AU - Tan, Ern Yu

AU - Chan, Patrick Mun Yew

AU - Muir, Kenneth

AU - Lophatananon, Artitaya

AU - Wu, Anna H

AU - Stram, Daniel O

AU - Matsuo, Keitaro

AU - Ito, Hidemi

AU - Chan, Ching Wan

AU - Ngeow, Joanne

AU - Yong, Wei Sean

AU - Lim, Swee Ho

AU - Lim, Geok Hoon

AU - Kwong, Ava

AU - Chan, Tsun L

AU - Tan, Su Ming

AU - Seah, Jaime

AU - John, Esther M

AU - Kurian, Allison W

AU - Koh, Woon-Puay

AU - Khor, Chiea Chuen

AU - Iwasaki, Motoki

AU - Yamaji, Taiki

AU - Tan, Kiak Mien Veronique

AU - Tan, Kiat Tee Benita

AU - Spinelli, John J

AU - Aronson, Kristan J

AU - Hasan, Siti Norhidayu

AU - Rahmat, Kartini

AU - Vijayananthan, Anushya

AU - Sim, Xueling

AU - Pharoah, Paul D P

AU - Zheng, Wei

AU - Dunning, Alison M

AU - Simard, Jacques

AU - van Dam, Rob Martinus

AU - Yip, Cheng-Har

AU - Taib, Nur Aishah Mohd

AU - Hartman, Mikael

AU - Easton, Douglas F

AU - Teo, Soo-Hwang

AU - Antoniou, Antonis C

PY - 2020/7/31

Y1 - 2020/7/31

N2 - Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

AB - Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

KW - Adult

KW - Aged

KW - Asia/epidemiology

KW - Breast Neoplasms/diagnosis

KW - Case-Control Studies

KW - Europe/epidemiology

KW - Female

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Middle Aged

KW - Multifactorial Inheritance

KW - Odds Ratio

KW - Polymorphism, Single Nucleotide

KW - Prognosis

KW - Risk

U2 - 10.1038/s41467-020-17680-w

DO - 10.1038/s41467-020-17680-w

M3 - Article

C2 - 32737321

SN - 2041-1723

VL - 11

SP - 3833

JO - Nature Communications

JF - Nature Communications

IS - 1

ER -

European polygenic risk score for prediction of breast cancer shows similar performance in Asian women

Abstract

Keywords

UN SDGs

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