Evaluating the Impact of Applying Personal Glucose Targets in a Closed-Loop System for People With Type 1 Diabetes

Mustafa Fattah, Charlotte K Boughton, Julia Ware, Janet M Allen, Sara Hartnell, Malgorzata E Willinska, Ajay Thankamony, Carine de Beaufort, Fiona M Campbell, Elke Fröhlich-Reiterer, Sabine E Hofer, Thomas M Kapellen, Birgit Rami-Merhar, Atrayee Ghatak, Tabitha L Randell, Rachel E J Besser, Daniela Elleri, Nicola Trevelyan, Louise Denvir Md, Nikki DavisLia Bally, Hood Thabit, Lalantha Leelarathna, Mark L Evans, Julia K Mader, Roman Hovorka

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: CamAPS FX is a hybrid closed-loop smartphone app used to manage type one diabetes. The closed-loop algorithm has a default target glucose of 5.8 mmol/L (104.5 mg/dL), but users can select personal glucose targets (adjustable between 4.4 mmol/L and 11.0 mmol/L [79 mg/dL and 198 mg/dL, respectively]).

METHOD: In this post-hoc analysis, we evaluated the impact of personal glucose targets on glycemic control using data from participants in five randomized controlled trials.

RESULTS: Personal glucose targets were widely used, with 20.3% of all days in the data set having a target outside the default target bin (5.5-6.0 mmol/L [99-108 mg/dL]). Personal glucose targets >6.5 mmol/L (117 mg/dL) were associated with significantly less time in target range (3.9-10.0 mmol/L [70-180 mg/dL]; 6.5-7.0 mmol/L [117-126 mg/dL]: mean difference = -3.2 percentage points [95% CI: -5.3 to -1.2; P < .001]; 7.0-7.5 mmol/L [126-135 mg/dL]: -10.8 percentage points [95% CI: -14.1 to -7.6; P < .001]). Personal targets >6.5 mmol/L (117 mg/dL) were associated with significantly lower time (<3.9 mmol/L [<70 mg/dL]; 6.5-7.0 mmol/L [117-126 mg/dL]: -1.85 percentage points [95% CI: -2.37 to -1.34; P < .001]; 7.0-7.5 mmol/L [126-135 mg/dL]: -2.68 percentage points [95% CI: -3.49 to -1.86; P < .001]).

CONCLUSIONS: Discrete study populations showed differences in glucose control when applying similar personal targets.

Original languageEnglish
Pages (from-to)19322968221145184
JournalJournal of Diabetes Science and Technology
DOIs
Publication statusE-pub ahead of print - 20 Dec 2022

Fingerprint

Dive into the research topics of 'Evaluating the Impact of Applying Personal Glucose Targets in a Closed-Loop System for People With Type 1 Diabetes'. Together they form a unique fingerprint.

Cite this