Evaluation of combined multi-chamber with compounded bags and multi-chamber bags only for British adults on home parenteral nutrition: A mixed methods pilot study

Karen Allsopp; Simon Lal; Anne Marie Sowerbutts; Debra Jones; Michael Taylor; Simon Harrison; Arun Abraham; Kirstine Farrer; Gavin Leahy; Antje Teubner; Sorrel Burden

doi:10.1016/j.intf.2025.100063

Evaluation of combined multi-chamber with compounded bags and multi-chamber bags only for British adults on home parenteral nutrition: A mixed methods pilot study

Karen Allsopp, Simon Lal, Anne Marie Sowerbutts, Debra Jones, Michael Taylor, Simon Harrison, Arun Abraham, Kirstine Farrer, Gavin Leahy, Antje Teubner, Sorrel Burden

Research output: Contribution to journal › Article › peer-review

Abstract

Background
People with chronic intestinal failure (IF) require home parenteral nutrition (HPN). Parenteral nutrition regimens can comprise of bespoke prescriptions compounded specifically for the individual, commercially produced multi-chamber bags (MCBs), or a combination of compounded and MCBs known as ‘hybrid’ regimens. This pilot study aimed to evaluate quality of life (QoL) and clinical outcomes with hybrid or MCBs-only parenteral nutrition regimens.
Methods
This mixed-methods pilot study collected data from patients between June 2022 and January 2023. Data were gathered at baseline and 180 days post-discharge. Patients were interviewed about their lived experiences and completed a QoL questionnaire. Quantitative data were analysed using descriptive statistics while qualitative data analysis used framework analysis.
Results
We recruited 28 patients, 16 on hybrid HPN regimens and 12 on MCBs. After 180 days, no catheter-related bloodstream infections were recorded. No differences were found between hybrid and MCBs-only regarding QoL. Patients on hybrid regimens reported no issues arising specifically from using two bag types, and some of those on MCBs-only appreciated extra flexibility in their lives.
Conclusions
Both MCB and hybrid HPN regimens were acceptable to patients, with neither showing a substantial difference in QoL.

Original language	Undefined
Journal	Intestinal Failure
Volume	5
DOIs	https://doi.org/10.1016/j.intf.2025.100063
Publication status	Published - May 2025

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10.1016/j.intf.2025.100063

Cite this

Allsopp, K., Lal, S., Sowerbutts, A. M., Jones, D., Taylor, M., Harrison, S., Abraham, A., Farrer, K., Leahy, G., Teubner, A., & Burden, S. (2025). Evaluation of combined multi-chamber with compounded bags and multi-chamber bags only for British adults on home parenteral nutrition: A mixed methods pilot study. Intestinal Failure, 5. https://doi.org/10.1016/j.intf.2025.100063

@article{06568560b1a045cf8ec1d910ad22ae61,

title = "Evaluation of combined multi-chamber with compounded bags and multi-chamber bags only for British adults on home parenteral nutrition: A mixed methods pilot study",

abstract = "BackgroundPeople with chronic intestinal failure (IF) require home parenteral nutrition (HPN). Parenteral nutrition regimens can comprise of bespoke prescriptions compounded specifically for the individual, commercially produced multi-chamber bags (MCBs), or a combination of compounded and MCBs known as {\textquoteleft}hybrid{\textquoteright} regimens. This pilot study aimed to evaluate quality of life (QoL) and clinical outcomes with hybrid or MCBs-only parenteral nutrition regimens.MethodsThis mixed-methods pilot study collected data from patients between June 2022 and January 2023. Data were gathered at baseline and 180 days post-discharge. Patients were interviewed about their lived experiences and completed a QoL questionnaire. Quantitative data were analysed using descriptive statistics while qualitative data analysis used framework analysis.ResultsWe recruited 28 patients, 16 on hybrid HPN regimens and 12 on MCBs. After 180 days, no catheter-related bloodstream infections were recorded. No differences were found between hybrid and MCBs-only regarding QoL. Patients on hybrid regimens reported no issues arising specifically from using two bag types, and some of those on MCBs-only appreciated extra flexibility in their lives.ConclusionsBoth MCB and hybrid HPN regimens were acceptable to patients, with neither showing a substantial difference in QoL.",

author = "Karen Allsopp and Simon Lal and Sowerbutts, {Anne Marie} and Debra Jones and Michael Taylor and Simon Harrison and Arun Abraham and Kirstine Farrer and Gavin Leahy and Antje Teubner and Sorrel Burden",

year = "2025",

month = may,

doi = "10.1016/j.intf.2025.100063",

language = "Undefined",

volume = "5",

journal = "Intestinal Failure",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Evaluation of combined multi-chamber with compounded bags and multi-chamber bags only for British adults on home parenteral nutrition: A mixed methods pilot study

AU - Allsopp, Karen

AU - Lal, Simon

AU - Sowerbutts, Anne Marie

AU - Jones, Debra

AU - Taylor, Michael

AU - Harrison, Simon

AU - Abraham, Arun

AU - Farrer, Kirstine

AU - Leahy, Gavin

AU - Teubner, Antje

AU - Burden, Sorrel

PY - 2025/5

Y1 - 2025/5

N2 - BackgroundPeople with chronic intestinal failure (IF) require home parenteral nutrition (HPN). Parenteral nutrition regimens can comprise of bespoke prescriptions compounded specifically for the individual, commercially produced multi-chamber bags (MCBs), or a combination of compounded and MCBs known as ‘hybrid’ regimens. This pilot study aimed to evaluate quality of life (QoL) and clinical outcomes with hybrid or MCBs-only parenteral nutrition regimens.MethodsThis mixed-methods pilot study collected data from patients between June 2022 and January 2023. Data were gathered at baseline and 180 days post-discharge. Patients were interviewed about their lived experiences and completed a QoL questionnaire. Quantitative data were analysed using descriptive statistics while qualitative data analysis used framework analysis.ResultsWe recruited 28 patients, 16 on hybrid HPN regimens and 12 on MCBs. After 180 days, no catheter-related bloodstream infections were recorded. No differences were found between hybrid and MCBs-only regarding QoL. Patients on hybrid regimens reported no issues arising specifically from using two bag types, and some of those on MCBs-only appreciated extra flexibility in their lives.ConclusionsBoth MCB and hybrid HPN regimens were acceptable to patients, with neither showing a substantial difference in QoL.

AB - BackgroundPeople with chronic intestinal failure (IF) require home parenteral nutrition (HPN). Parenteral nutrition regimens can comprise of bespoke prescriptions compounded specifically for the individual, commercially produced multi-chamber bags (MCBs), or a combination of compounded and MCBs known as ‘hybrid’ regimens. This pilot study aimed to evaluate quality of life (QoL) and clinical outcomes with hybrid or MCBs-only parenteral nutrition regimens.MethodsThis mixed-methods pilot study collected data from patients between June 2022 and January 2023. Data were gathered at baseline and 180 days post-discharge. Patients were interviewed about their lived experiences and completed a QoL questionnaire. Quantitative data were analysed using descriptive statistics while qualitative data analysis used framework analysis.ResultsWe recruited 28 patients, 16 on hybrid HPN regimens and 12 on MCBs. After 180 days, no catheter-related bloodstream infections were recorded. No differences were found between hybrid and MCBs-only regarding QoL. Patients on hybrid regimens reported no issues arising specifically from using two bag types, and some of those on MCBs-only appreciated extra flexibility in their lives.ConclusionsBoth MCB and hybrid HPN regimens were acceptable to patients, with neither showing a substantial difference in QoL.

UR - https://doi.org/10.1016/j.intf.2025.100063

U2 - 10.1016/j.intf.2025.100063

DO - 10.1016/j.intf.2025.100063

M3 - Article

VL - 5

JO - Intestinal Failure

JF - Intestinal Failure

ER -

Evaluation of combined multi-chamber with compounded bags and multi-chamber bags only for British adults on home parenteral nutrition: A mixed methods pilot study

Abstract

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HARG: Healthy Ageing Research Group

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Evaluation of combined multi-chamber with compounded bags and multi-chamber bags only for British adults on home parenteral nutrition: A mixed methods pilot study

Abstract

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Projects

HARG: Healthy Ageing Research Group

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