Evaluation of DLA promoters in Doberman hepatitis

H. Dyggve; S. Meri; T. Spillmann; H. Lohi; L. J. Kennedy; M. Speeti

doi:10.1111/j.1399-0039.2011.01784.x

Evaluation of DLA promoters in Doberman hepatitis

H. Dyggve, S. Meri, T. Spillmann, H. Lohi, L. J. Kennedy, M. Speeti

Research output: Contribution to journal › Article › peer-review

Abstract

Doberman hepatitis (DH) is associated with homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 indicating a role for the immune system in the development of the disease. The dog leucocyte antigen (DLA) class II expression is controlled at the transcriptional level with proximal promoters. Differential expression of DLA class II molecules of antigen-presenting cells is reported to affect susceptibility to or protection from different immune-mediated diseases. The aim of this study was to evaluate, whether the variation in promoter areas of homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 Dobermans could explain why some dogs become afflicted with DH and others do not. Our findings suggest that promoter variants are not associated as risk modifiers in homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 Dobermans, but additional factors are needed. Nevertheless, our study indicates that the whole DLA block is associated to the disease. © 2011 John Wiley & Sons A/S.

Original language	English
Pages (from-to)	446-450
Number of pages	4
Journal	Tissue Antigens
Volume	78
Issue number	6
DOIs	https://doi.org/10.1111/j.1399-0039.2011.01784.x
Publication status	Published - Dec 2011

Keywords

Canine major histocompatibility complex
DLA-DRA
Doberman hepatitis
Promoter

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1399-0039.2011.01784.x

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title = "Evaluation of DLA promoters in Doberman hepatitis",

abstract = "Doberman hepatitis (DH) is associated with homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 indicating a role for the immune system in the development of the disease. The dog leucocyte antigen (DLA) class II expression is controlled at the transcriptional level with proximal promoters. Differential expression of DLA class II molecules of antigen-presenting cells is reported to affect susceptibility to or protection from different immune-mediated diseases. The aim of this study was to evaluate, whether the variation in promoter areas of homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 Dobermans could explain why some dogs become afflicted with DH and others do not. Our findings suggest that promoter variants are not associated as risk modifiers in homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 Dobermans, but additional factors are needed. Nevertheless, our study indicates that the whole DLA block is associated to the disease. {\textcopyright} 2011 John Wiley & Sons A/S.",

keywords = "Canine major histocompatibility complex, DLA-DRA, Doberman hepatitis, Promoter",

author = "H. Dyggve and S. Meri and T. Spillmann and H. Lohi and Kennedy, {L. J.} and M. Speeti",

year = "2011",

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language = "English",

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T1 - Evaluation of DLA promoters in Doberman hepatitis

AU - Dyggve, H.

AU - Meri, S.

AU - Spillmann, T.

AU - Lohi, H.

AU - Kennedy, L. J.

AU - Speeti, M.

PY - 2011/12

Y1 - 2011/12

N2 - Doberman hepatitis (DH) is associated with homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 indicating a role for the immune system in the development of the disease. The dog leucocyte antigen (DLA) class II expression is controlled at the transcriptional level with proximal promoters. Differential expression of DLA class II molecules of antigen-presenting cells is reported to affect susceptibility to or protection from different immune-mediated diseases. The aim of this study was to evaluate, whether the variation in promoter areas of homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 Dobermans could explain why some dogs become afflicted with DH and others do not. Our findings suggest that promoter variants are not associated as risk modifiers in homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 Dobermans, but additional factors are needed. Nevertheless, our study indicates that the whole DLA block is associated to the disease. © 2011 John Wiley & Sons A/S.

AB - Doberman hepatitis (DH) is associated with homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 indicating a role for the immune system in the development of the disease. The dog leucocyte antigen (DLA) class II expression is controlled at the transcriptional level with proximal promoters. Differential expression of DLA class II molecules of antigen-presenting cells is reported to affect susceptibility to or protection from different immune-mediated diseases. The aim of this study was to evaluate, whether the variation in promoter areas of homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 Dobermans could explain why some dogs become afflicted with DH and others do not. Our findings suggest that promoter variants are not associated as risk modifiers in homozygous DLA-DRB1*00601/DQA1*00401/DQB1*01303 Dobermans, but additional factors are needed. Nevertheless, our study indicates that the whole DLA block is associated to the disease. © 2011 John Wiley & Sons A/S.

KW - Canine major histocompatibility complex

KW - DLA-DRA

KW - Doberman hepatitis

KW - Promoter

U2 - 10.1111/j.1399-0039.2011.01784.x

DO - 10.1111/j.1399-0039.2011.01784.x

M3 - Article

C2 - 22077625

SN - 0001-2815

VL - 78

SP - 446

EP - 450

JO - Tissue Antigens

JF - Tissue Antigens

IS - 6

ER -

Evaluation of DLA promoters in Doberman hepatitis

Abstract

Keywords

UN SDGs

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