Evaluation of the Benefit of Partial Volume Correction for High Resolution PET Scanners

Evangelos Raptis, Laura M. Parkes, Jose M. Anton-Rodriguez, Stephen F. Carter, Karl Herholz, Julian C. Matthews

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The benefit of partial volume correction (PVC) within and post image reconstruction for high resolution PET scanners was examined. Listmode data from a realistic simulation of the HRRT that represented radioactivity and matter distributions for amyloid negative, amyloid positive and FDG scans in the head were conducted and reconstructed using the HRRT community software. PVC methods of Lucy-Richardson deconvolution and Rousset were applied both within and post reconstruction. Hammers' atlas brain regions that were predominantly both grey and white matter were applied to the images and the ground truth. For all three simulated scans (FDG, amyloid negative and amyloid positive) there was very little benefit of Lucy-Richardson deconvolution both within and post reconstruction. For Rousset PVC, both within and post image reconstruction, there was a reduction on average in the bias. However, a large region-specific bias was observed which was larger for the small regions and when PVC was applied within image reconstruction. This work casts doubt on the benefit of PVC for high resolution PET scanners with further work needed to evaluate whether PVC is of value.

Original languageEnglish
Title of host publication2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
PublisherIEEE
ISBN (Electronic)9781728141640
DOIs
Publication statusPublished - Oct 2019
Event2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019 - Manchester, United Kingdom
Duration: 26 Oct 20192 Nov 2019

Publication series

Name2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019

Conference

Conference2019 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2019
Country/TerritoryUnited Kingdom
CityManchester
Period26/10/192/11/19

Keywords

  • High Resolution
  • Partial Volume Correction
  • Positron Emission Tomography

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