Evaluation of the specificity and effectiveness of selected oral hygiene actives in salivary biofilm microcosms

Ruth G. Ledder; Prem K. Sreenivasan; William DeVizio; Andrew J. McBain

doi:10.1099/jmm.0.024372-0

Evaluation of the specificity and effectiveness of selected oral hygiene actives in salivary biofilm microcosms

Ruth G. Ledder, Prem K. Sreenivasan, William DeVizio, Andrew J. McBain

Research output: Contribution to journal › Article › peer-review

Abstract

The microbiological effects of biocidal products used for the enhancement of oral hygiene relate to the active compound(s) as well as other formulation components. Here, we test the specificities of selected actives in the absence of multiple excipients. Salivary ecosystems were maintained in tissue culture plate-based hydroxyapatite disc models (HDMs) and modified drip-flow biofilm reactors (MDFRs). Test compounds stannous fluoride (SF), SDS, triclosan (TCS), zinc lactate (ZL) and ZL with SF in combination (ZLSF) were delivered to the HDMs once and four times daily for 6 days to MDFRs. Plaques were characterized by differential viable counting and PCR-denaturing gradient gel electrophoresis (DGGE). TCS and SDS were the most effective compounds against HDM plaques, significantly reducing total viable counts (P

Original language	English
Pages (from-to)	1462-1468
Number of pages	6
Journal	Journal of medical microbiology
Volume	59
Issue number	12
DOIs	https://doi.org/10.1099/jmm.0.024372-0
Publication status	Published - Dec 2010

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10.1099/jmm.0.024372-0

http://jmm.sgmjournals.org/cgi/reprint/59/12/1462

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Evaluation of the specificity and effectiveness of selected oral hygiene actives in salivary biofilm microcosms

Abstract

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