TY - JOUR
T1 - Evaluation of tumor shape variability in head-and-neck cancer patients over the course of radiation therapy using implanted gold markers.
AU - Van Herk, Marcel
AU - Hamming-Vrieze, Olga
AU - van Kranen, Simon Robert
AU - van Beek, Suzanne
AU - Heemsbergen, Wilma
AU - van Herk, Marcel
AU - van den Brekel, Michiel Wilhelmus Maria
AU - Sonke, Jan-Jakob
AU - Rasch, Coenraad Robert Nico
PY - 2012/10/1
Y1 - 2012/10/1
N2 - PURPOSE: This study quantifies tumor shape variability in head-and-neck cancer patients during radiation therapy using implanted markers. METHODS AND MATERIALS: Twenty-seven patients with oropharyngeal tumors treated with (chemo)radiation were included. Helical gold markers (0.35 × 2 mm, 3-10/patient, average 6) were implanted around the tumor. Markers were identified on planning computed tomography (CT) and daily cone beam CT (CBCT). After bony anatomy registration, the daily vector length on CBCT in reference to the planning CT and daily marker movement perpendicular to the gross tumor volume (GTV) surface at planning CT (d(normal)) of each marker were analyzed. Time trends were assessed with linear regression of the (markers). In 2 patients, 2 markers were implanted in normal tissue to evaluate migration by measuring intermarker distances. RESULTS: Marker implantation was feasible without complications. Three-dimensional vectors (4827 measurements, mean 0.23 cm, interquartile ratio 0.24 cm) were highest in base of tongue sublocalization (P
AB - PURPOSE: This study quantifies tumor shape variability in head-and-neck cancer patients during radiation therapy using implanted markers. METHODS AND MATERIALS: Twenty-seven patients with oropharyngeal tumors treated with (chemo)radiation were included. Helical gold markers (0.35 × 2 mm, 3-10/patient, average 6) were implanted around the tumor. Markers were identified on planning computed tomography (CT) and daily cone beam CT (CBCT). After bony anatomy registration, the daily vector length on CBCT in reference to the planning CT and daily marker movement perpendicular to the gross tumor volume (GTV) surface at planning CT (d(normal)) of each marker were analyzed. Time trends were assessed with linear regression of the (markers). In 2 patients, 2 markers were implanted in normal tissue to evaluate migration by measuring intermarker distances. RESULTS: Marker implantation was feasible without complications. Three-dimensional vectors (4827 measurements, mean 0.23 cm, interquartile ratio 0.24 cm) were highest in base of tongue sublocalization (P
U2 - 10.1016/j.ijrobp.2012.03.014
DO - 10.1016/j.ijrobp.2012.03.014
M3 - Article
C2 - 22560548
SN - 0360-3016
VL - 84
JO - International journal of radiation oncology, biology, physics
JF - International journal of radiation oncology, biology, physics
IS - 2
ER -