TY - JOUR
T1 - Evening and morning exhaled volatile compound patterns are different in obstructive sleep apnoea assessed with electronic nose
AU - Kunos, L.
AU - Bikov, A.
AU - Lazar, Z.
AU - Korosi, B.Z.
AU - Benedek, P.
AU - Losonczy, G.
AU - Horvath, I.
N1 - Cited By :17
Export Date: 31 October 2018
CODEN: SBLRB
Correspondence Address: Bikov, A.; Department of Pulmonology, Semmelweis University, 1/C Dios arok, Hungary; email: [email protected]
Chemicals/CAS: Volatile Organic Compounds
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PY - 2015
Y1 - 2015
N2 - Purpose: Electronic noses represent a technique for the measurement of exhaled breath volatile compound pattern which can discriminate patients with obstructive sleep apnoea (OSA) from control subjects. Although overnight changes in circulating biomarkers were reported, this effect on the exhaled volatile compound pattern has not been studied before. We aimed to compare breath patterns in the evening and in the morning in patients with OSA and to study the ability of the electronic nose to distinguish patients from controls based on these exhaled volatile patterns. Methods: Exhaled breath volatile compound pattern was measured before and after night in 26 patients with suspected sleep-disordered breathing (53 ± 15 years) who underwent polysomnography and in ten control subjects (37 ± 15 years), by whom sleep-disordered breathing was excluded with a home apnoea screening device. Breath measurements were also performed in the morning in 26 healthy, non-smoking age-matched controls (48 ± 10 years) with no complaints about disturbed sleep. Exhaled volatile compound pattern was processed with a Cyranose 320 electronic nose, and principal component analysis was used for statistical analysis. Results: Exhaled volatile compound patterns recorded in the evening and in the morning were different in patients with OSA (p = 0.01) but not in non-OSA habitual snorers (p = 0.49) or in control subjects (p = 0.23). The electronic nose distinguished patients with OSA from control subjects based on the breath samples collected in the morning (p <0.001, classification accuracy 77 %) but not in the evening (p > 0.05). Conclusions: Evening and morning exhaled volatile compound patterns are different in OSA. This might affect the ability of electronic noses to identify this disorder. Overnight alterations in volatile substances need to be taken into account during exhaled breath measurements in OSA. © 2014, Springer-Verlag Berlin Heidelberg.
AB - Purpose: Electronic noses represent a technique for the measurement of exhaled breath volatile compound pattern which can discriminate patients with obstructive sleep apnoea (OSA) from control subjects. Although overnight changes in circulating biomarkers were reported, this effect on the exhaled volatile compound pattern has not been studied before. We aimed to compare breath patterns in the evening and in the morning in patients with OSA and to study the ability of the electronic nose to distinguish patients from controls based on these exhaled volatile patterns. Methods: Exhaled breath volatile compound pattern was measured before and after night in 26 patients with suspected sleep-disordered breathing (53 ± 15 years) who underwent polysomnography and in ten control subjects (37 ± 15 years), by whom sleep-disordered breathing was excluded with a home apnoea screening device. Breath measurements were also performed in the morning in 26 healthy, non-smoking age-matched controls (48 ± 10 years) with no complaints about disturbed sleep. Exhaled volatile compound pattern was processed with a Cyranose 320 electronic nose, and principal component analysis was used for statistical analysis. Results: Exhaled volatile compound patterns recorded in the evening and in the morning were different in patients with OSA (p = 0.01) but not in non-OSA habitual snorers (p = 0.49) or in control subjects (p = 0.23). The electronic nose distinguished patients with OSA from control subjects based on the breath samples collected in the morning (p <0.001, classification accuracy 77 %) but not in the evening (p > 0.05). Conclusions: Evening and morning exhaled volatile compound patterns are different in OSA. This might affect the ability of electronic noses to identify this disorder. Overnight alterations in volatile substances need to be taken into account during exhaled breath measurements in OSA. © 2014, Springer-Verlag Berlin Heidelberg.
KW - Breath test
KW - Electronic nose
KW - OSA
KW - Sleep
KW - Volatile organic compounds
KW - biological marker
KW - volatile agent
KW - volatile organic compound
KW - accuracy
KW - adult
KW - Article
KW - breath analysis
KW - clinical article
KW - controlled study
KW - electronic nose
KW - expired air
KW - human
KW - night
KW - polysomnography
KW - priority journal
KW - sleep disordered breathing
KW - smoking
KW - snoring
KW - spirometry
KW - age
KW - aged
KW - case control study
KW - circadian rhythm
KW - female
KW - male
KW - middle aged
KW - pathophysiology
KW - physiology
KW - reference value
KW - Sleep Apnea, Obstructive
KW - Adult
KW - Age Factors
KW - Aged
KW - Breath Tests
KW - Case-Control Studies
KW - Circadian Rhythm
KW - Electronic Nose
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Polysomnography
KW - Reference Values
KW - Volatile Organic Compounds
U2 - 10.1007/s11325-014-1003-z
DO - 10.1007/s11325-014-1003-z
M3 - Article
SN - 1520-9512
VL - 19
SP - 247
EP - 253
JO - Sleep and Breathing
JF - Sleep and Breathing
IS - 1
ER -