Evidence against putrescine and polyamines as endogenous mediators of fever

M. J. Dascombe, K. D. Haegele

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Endogenous concentrations of putrescine, spermidine, spermine and related biosynthetic enzymes were not affected by the administration of bacterial endotoxin and the subsequent development of fever in rabbits. In addition, the febrile response to endotoxin was unaffected either by the ornithine decarboxylase inhibitor, DL-α-difluoromethylornithine or by putresceine. These data indicate polyamines are not involved in the development of fever.
    Original languageEnglish
    Pages (from-to)365-366
    Number of pages1
    JournalJournal of Pharmacy and Pharmacology
    Volume37
    Issue number5
    Publication statusPublished - 1985

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