Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries

Jacqueline Ohanian; Kelly M. Gatfield; Donald T. Ward; Vasken Ohanian

doi:10.1152/ajpheart.00739.2004

Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries

Jacqueline Ohanian, Kelly M. Gatfield, Donald T. Ward, Vasken Ohanian

Research output: Contribution to journal › Article › peer-review

Abstract

Myogenic tone of small arteries is dependent on the presence of extracellular calcium (Cao2+), and, recently, a receptor that senses changes in Ca2+, the calcium-sensing receptor (CaR), has been detected in vascular tissue. We investigated whether the CaR is involved in the regulation of myogenic tone in rat subcutaneous small arteries. Immunoblot analysis using a monoclonal antibody against the CaR demonstrated its presence in rat subcutaneous arteries. To determine whether the CaR was functionally active, segments of artery (

Original language	English
Pages (from-to)	H1756-H1762
Journal	American Journal of Physiology: Heart and Circulatory Physiology
Volume	288
Issue number	4
DOIs	https://doi.org/10.1152/ajpheart.00739.2004
Publication status	Published - Apr 2005

Keywords

Aminoglycosides
Contractility
Magnesium
Peripheral vascular resistance
Vascular smooth muscle

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1152/ajpheart.00739.2004

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title = "Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries",

abstract = "Myogenic tone of small arteries is dependent on the presence of extracellular calcium (Cao2+), and, recently, a receptor that senses changes in Ca2+, the calcium-sensing receptor (CaR), has been detected in vascular tissue. We investigated whether the CaR is involved in the regulation of myogenic tone in rat subcutaneous small arteries. Immunoblot analysis using a monoclonal antibody against the CaR demonstrated its presence in rat subcutaneous arteries. To determine whether the CaR was functionally active, segments of artery (",

keywords = "Aminoglycosides, Contractility, Magnesium, Peripheral vascular resistance, Vascular smooth muscle",

author = "Jacqueline Ohanian and Gatfield, {Kelly M.} and Ward, {Donald T.} and Vasken Ohanian",

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AU - Ohanian, Jacqueline

AU - Gatfield, Kelly M.

AU - Ward, Donald T.

AU - Ohanian, Vasken

PY - 2005/4

Y1 - 2005/4

N2 - Myogenic tone of small arteries is dependent on the presence of extracellular calcium (Cao2+), and, recently, a receptor that senses changes in Ca2+, the calcium-sensing receptor (CaR), has been detected in vascular tissue. We investigated whether the CaR is involved in the regulation of myogenic tone in rat subcutaneous small arteries. Immunoblot analysis using a monoclonal antibody against the CaR demonstrated its presence in rat subcutaneous arteries. To determine whether the CaR was functionally active, segments of artery (

AB - Myogenic tone of small arteries is dependent on the presence of extracellular calcium (Cao2+), and, recently, a receptor that senses changes in Ca2+, the calcium-sensing receptor (CaR), has been detected in vascular tissue. We investigated whether the CaR is involved in the regulation of myogenic tone in rat subcutaneous small arteries. Immunoblot analysis using a monoclonal antibody against the CaR demonstrated its presence in rat subcutaneous arteries. To determine whether the CaR was functionally active, segments of artery (

KW - Aminoglycosides

KW - Contractility

KW - Magnesium

KW - Peripheral vascular resistance

KW - Vascular smooth muscle

U2 - 10.1152/ajpheart.00739.2004

DO - 10.1152/ajpheart.00739.2004

M3 - Article

C2 - 15576443

SN - 0363-6135

VL - 288

SP - H1756-H1762

JO - American Journal of Physiology: Heart and Circulatory Physiology

JF - American Journal of Physiology: Heart and Circulatory Physiology

IS - 4

ER -

Evidence for a functional calcium-sensing receptor that modulates myogenic tone in rat subcutaneous small arteries

Abstract

Keywords

UN SDGs

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