Evidence for epoxide formation from isopenicillin N synthase

Jack E. Baldwin; Robert M. Adlington; M. Bradley; N. J. Turner; A. R. Pitt

doi:10.1039/C39890000978

Evidence for epoxide formation from isopenicillin N synthase

Jack E. Baldwin^*, Robert M. Adlington, M. Bradley, N. J. Turner, A. R. Pitt

^*Corresponding author for this work

Oxford University

Research output: Contribution to journal › Article › peer-review

Abstract

Isolation of a new β-lactam-containing metabolite, from incubation of the three deuteriated tripeptides (1b-d) with isopencillin N synthase (IPNS) has provided evidence of an epoxide type intermediate; a unified mechanism is proposed for the formation of products by IPNS from unsaturated precursors.

Original language	English
Pages (from-to)	978-981
Number of pages	4
Journal	Journal of the Chemical Society, Chemical Communications
Volume	1989
Issue number	15
DOIs	https://doi.org/10.1039/C39890000978
Publication status	Published - 1989

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@article{2a473a086bca42989b73da71fe6396b3,

title = "Evidence for epoxide formation from isopenicillin N synthase",

abstract = "Isolation of a new β-lactam-containing metabolite, from incubation of the three deuteriated tripeptides (1b-d) with isopencillin N synthase (IPNS) has provided evidence of an epoxide type intermediate; a unified mechanism is proposed for the formation of products by IPNS from unsaturated precursors.",

author = "Baldwin, \{Jack E.\} and Adlington, \{Robert M.\} and M. Bradley and Turner, \{N. J.\} and Pitt, \{A. R.\}",

year = "1989",

doi = "10.1039/C39890000978",

language = "English",

volume = "1989",

pages = "978--981",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

publisher = "Chemical Society",

number = "15",

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TY - JOUR

T1 - Evidence for epoxide formation from isopenicillin N synthase

AU - Baldwin, Jack E.

AU - Adlington, Robert M.

AU - Bradley, M.

AU - Turner, N. J.

AU - Pitt, A. R.

PY - 1989

Y1 - 1989

N2 - Isolation of a new β-lactam-containing metabolite, from incubation of the three deuteriated tripeptides (1b-d) with isopencillin N synthase (IPNS) has provided evidence of an epoxide type intermediate; a unified mechanism is proposed for the formation of products by IPNS from unsaturated precursors.

AB - Isolation of a new β-lactam-containing metabolite, from incubation of the three deuteriated tripeptides (1b-d) with isopencillin N synthase (IPNS) has provided evidence of an epoxide type intermediate; a unified mechanism is proposed for the formation of products by IPNS from unsaturated precursors.

UR - https://www.scopus.com/pages/publications/37049088151

U2 - 10.1039/C39890000978

DO - 10.1039/C39890000978

M3 - Article

AN - SCOPUS:37049088151

SN - 0022-4936

VL - 1989

SP - 978

EP - 981

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 15

ER -

Evidence for epoxide formation from isopenicillin N synthase

Abstract

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