Evidence for protein conformational change at a Au(110)/protein interface

H. L. Messiha, C. I. Smith, N. S. Scrutton, P. Weightman

    Research output: Contribution to journalArticlepeer-review


    Evidence is presented that reflection anisotropy spectroscopy (RAS) can provide real-time measurements of conformational change in proteins induced by electron transfer reactions. A bacterial electron transferring flavoprotein (ETF) has been modified so as to adsorb on an Au(110) electrode and enable reversible electron transfer to the protein cofactor in the absence of mediators. Reversible changes are observed in the RAS of this protein that are interpreted as arising from conformational changes accompanying the transfer of electrons. Copyright © EPLA, 2008.
    Original languageEnglish
    Article number18004
    Issue number1
    Publication statusPublished - 1 Jul 2008


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