Evidence of recombination between divergent hepatitis E viruses

Hélène Van Cuyck; Jun Fan; David L. Robertson; Pierre Roques

doi:10.1128/JVI.79.14.9306-9314.2005

Evidence of recombination between divergent hepatitis E viruses

Hélène Van Cuyck, Jun Fan, David L. Robertson, Pierre Roques

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Abstract

Phylogenetic and recombination analysis was performed on 32 complete hepatitis E virus (HEV) genomes from infected humans and pigs. For the first time, evidence for recombination between divergent HEV strains was obtained, with at least two strains being found to have discordant phylogenetic relationships consistent with the occurrence of intragenotype recombination. This finding confirms that humans can be dually infected with divergent HEV strains and has implications for the emergence and evolution of new HEV epidemics. Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	9306-9314
Number of pages	8
Journal	Journal of virology
Volume	79
Issue number	14
DOIs	https://doi.org/10.1128/JVI.79.14.9306-9314.2005
Publication status	Published - Jul 2005

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10.1128/JVI.79.14.9306-9314.2005

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abstract = "Phylogenetic and recombination analysis was performed on 32 complete hepatitis E virus (HEV) genomes from infected humans and pigs. For the first time, evidence for recombination between divergent HEV strains was obtained, with at least two strains being found to have discordant phylogenetic relationships consistent with the occurrence of intragenotype recombination. This finding confirms that humans can be dually infected with divergent HEV strains and has implications for the emergence and evolution of new HEV epidemics. Copyright {\textcopyright} 2005, American Society for Microbiology. All Rights Reserved.",

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AU - Fan, Jun

AU - Robertson, David L.

AU - Roques, Pierre

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AB - Phylogenetic and recombination analysis was performed on 32 complete hepatitis E virus (HEV) genomes from infected humans and pigs. For the first time, evidence for recombination between divergent HEV strains was obtained, with at least two strains being found to have discordant phylogenetic relationships consistent with the occurrence of intragenotype recombination. This finding confirms that humans can be dually infected with divergent HEV strains and has implications for the emergence and evolution of new HEV epidemics. Copyright © 2005, American Society for Microbiology. All Rights Reserved.

U2 - 10.1128/JVI.79.14.9306-9314.2005

DO - 10.1128/JVI.79.14.9306-9314.2005

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VL - 79

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EP - 9314

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Evidence of recombination between divergent hepatitis E viruses

Abstract

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