Evolution of microglial activation in patients after ischemic stroke: A [11C](R)-PK11195 PET study

Alexander Gerhard; Johannes Schwarz; Ralph Myers; Richard Wise; Richard B. Banati

doi:10.1016/j.neuroimage.2004.09.034

Evolution of microglial activation in patients after ischemic stroke: A [11C](R)-PK11195 PET study

Alexander Gerhard, Johannes Schwarz, Ralph Myers, Richard Wise, Richard B. Banati

Research output: Contribution to journal › Article › peer-review

Abstract

We obtained [11C](R)-PK11195 PET scans in six patients at different time points between 3 and 150 days after onset of ischemic stroke in order to measure the time course of microglial activation. Increased [ 11C](R)-PK11195 binding around the lesion was observed as early as 3 days. Scans at later time points showed ongoing changes in the distribution of the [11C](R)-PK11195 signal, involving the area of the primary lesion and areas distant from the primary lesion site. Our data suggest that [ 11C](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration. © 2004 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	591-595
Number of pages	4
Journal	NeuroImage
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/j.neuroimage.2004.09.034
Publication status	Published - 15 Jan 2005

Keywords

[11C](R)-PK11195 PET
Activated microglia
Ischemic stroke
Peripheral benzodiazepine binding site

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.neuroimage.2004.09.034

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title = "Evolution of microglial activation in patients after ischemic stroke: A [11C](R)-PK11195 PET study",

abstract = "We obtained [11C](R)-PK11195 PET scans in six patients at different time points between 3 and 150 days after onset of ischemic stroke in order to measure the time course of microglial activation. Increased [ 11C](R)-PK11195 binding around the lesion was observed as early as 3 days. Scans at later time points showed ongoing changes in the distribution of the [11C](R)-PK11195 signal, involving the area of the primary lesion and areas distant from the primary lesion site. Our data suggest that [ 11C](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration. {\textcopyright} 2004 Elsevier Inc. All rights reserved.",

keywords = "[11C](R)-PK11195 PET, Activated microglia, Ischemic stroke, Peripheral benzodiazepine binding site",

author = "Alexander Gerhard and Johannes Schwarz and Ralph Myers and Richard Wise and Banati, {Richard B.}",

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T1 - Evolution of microglial activation in patients after ischemic stroke: A [11C](R)-PK11195 PET study

AU - Gerhard, Alexander

AU - Schwarz, Johannes

AU - Myers, Ralph

AU - Wise, Richard

AU - Banati, Richard B.

PY - 2005/1/15

Y1 - 2005/1/15

N2 - We obtained [11C](R)-PK11195 PET scans in six patients at different time points between 3 and 150 days after onset of ischemic stroke in order to measure the time course of microglial activation. Increased [ 11C](R)-PK11195 binding around the lesion was observed as early as 3 days. Scans at later time points showed ongoing changes in the distribution of the [11C](R)-PK11195 signal, involving the area of the primary lesion and areas distant from the primary lesion site. Our data suggest that [ 11C](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration. © 2004 Elsevier Inc. All rights reserved.

AB - We obtained [11C](R)-PK11195 PET scans in six patients at different time points between 3 and 150 days after onset of ischemic stroke in order to measure the time course of microglial activation. Increased [ 11C](R)-PK11195 binding around the lesion was observed as early as 3 days. Scans at later time points showed ongoing changes in the distribution of the [11C](R)-PK11195 signal, involving the area of the primary lesion and areas distant from the primary lesion site. Our data suggest that [ 11C](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration. © 2004 Elsevier Inc. All rights reserved.

KW - [11C](R)-PK11195 PET

KW - Activated microglia

KW - Ischemic stroke

KW - Peripheral benzodiazepine binding site

U2 - 10.1016/j.neuroimage.2004.09.034

DO - 10.1016/j.neuroimage.2004.09.034

M3 - Article

SN - 1053-8119

VL - 24

SP - 591

EP - 595

JO - NeuroImage

JF - NeuroImage

IS - 2

ER -

Evolution of microglial activation in patients after ischemic stroke: A [11C](R)-PK11195 PET study

Abstract

Keywords

UN SDGs

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