Evolution of neuroglia

Alexei Verkhratsky, Margaret S. Ho, Vladimir Parpura

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

As the nervous system evolved from the diffused to centralised form, the neurones were joined by the appearance of the supportive cells, the neuroglia. Arguably, these non-neuronal cells evolve into a more diversified cell family than the neurones are. The first ancestral neuroglia appeared in flatworms being mesenchymal in origin. In the nematode C. elegans proto-astrocytes/supportive glia of ectodermal origin emerged, albeit the ensheathment of axons by glial cells occurred later in prawns. The multilayered myelin occurred by convergent evolution of oligodendrocytes and Schwann cells in vertebrates above the jawless fishes. Nutritive partitioning of the brain from the rest of the body appeared in insects when the hemolymph-brain barrier, a predecessor of the blood-brain barrier was formed. The defensive cellular mechanism required specialisation of bona fide immune cells, microglia, a process that occurred in the nervous system of leeches, bivalves, snails, insects and above. In ascending phylogeny, new type of glial cells, such as scaffolding radial glia, appeared and as the bran sizes enlarged, the glia to neurone ratio increased. Humans possess some unique glial cells not seen in other animals.

Original languageEnglish
Title of host publicationNeuroglia in Neurodegenerative Diseases
EditorsAlexei Verkhratsky, Margaret S. Ho, Robert Zorec, Vladimir Parpura
PublisherSpringer Nature
Chapter2
Pages15-44
Number of pages30
ISBN (Electronic)978-981-13-9913-8
ISBN (Print)978-981-13-9912-1
DOIs
Publication statusPublished - 1 Jan 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1175
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Astrocytes
  • Blood/haemolymph-brain barrier
  • Brain size
  • Complexity of glia
  • Glia to neuron ratio
  • Microglia
  • Myelination
  • Oligodendrocytes
  • Radial glia

Fingerprint

Dive into the research topics of 'Evolution of neuroglia'. Together they form a unique fingerprint.

Cite this