Exclusion of the genes CDKN2 and PTEN as causative gene defects in Li-Fraumeni syndrome

E. C. Burt, G. McGown, M. Thorncroft, L. A. James, J. M. Birch, J. M. Varley

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We have analysed Li-Fraumeni syndrome families, previously shown to be negative for mutations in TP53, for mutations to the tumour suppressor genes PTEN and CDKN2. These genes function in cell cycle progression or are mutated in a variety of tumours. We have detected no mutations in the family members tested.
    Original languageEnglish
    Pages (from-to)9-10
    Number of pages1
    JournalBritish Journal of Cancer
    Volume80
    Issue number1-2
    DOIs
    Publication statusPublished - 1999

    Keywords

    • CDKN2
    • Li-Fraumeni syndrome
    • p16
    • p19(ARF)
    • PTEN

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