@article{928503e2c35f495ca9e8a090a39fd11a,
title = "Expanding the synthetic scope of biocatalysis by enzyme discovery and protein engineering",
abstract = "Despite the growing impact of enzyme catalysis in industrial chemistry, the full potential of this technology is yet to be unlocked. Accessing new chemistries and expanding the scope of existing reactions is necessary in order to make biocatalysis a pivotal technology in the manufacturing of chemicals across the whole industrial spectrum. This review highlights how the biocatalytic toolbox for synthetic chemistry has recently been expanded by extending the scope of industrially relevant reactions, and the addition of new reactions via enzyme discovery or protein engineering.",
keywords = "Amides, Biocatalysis, Carbene and nitrene transfers, Enzyme discovery, Halogenases, Protein engineering",
author = "Nicholas Turner and James Marshall and Juan Mangas-Sanchez",
note = "Funding Information: We would like to thank the Industrial Biotechnology Innovation Centre (IBioIC) and Biotechnology and Biological Sciences Research Council (BBSRC) for the awarding the CASE studentship to J.R.M from Prozomix Ltd. J.M ? S thanks the ARAID Foundation for personal funding and the Research Group E07_20R for scientific support. N.J.T is grateful to the ERC for the award of an Advanced Grant (Grant number 742987). Special thanks to Dr. Sebastian C. Cosgrove for proof reading and feedback. Funding Information: We would like to thank the Industrial Biotechnology Innovation Centre (IBioIC) and Biotechnology and Biological Sciences Research Council (BBSRC) for the awarding the CASE studentship to J.R.M from Prozomix Ltd. J.M − S thanks the ARAID Foundation for personal funding and the Research Group E07_20R for scientific support. N.J.T is grateful to the ERC for the award of an Advanced Grant (Grant number 742987 ). Special thanks to Dr. Sebastian C. Cosgrove for proof reading and feedback. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",
year = "2021",
month = feb,
day = "26",
doi = "10.1016/j.tet.2021.131926",
language = "English",
volume = "82",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier BV",
}