Expeditious, potentially primordial, aminoacylation of nucleotides

Jean Philippe Biron, Alastair L. Parkes, Robert Pascal, John D. Sutherland

    Research output: Contribution to journalArticlepeer-review


    (Chemical Equation Presented) In the beginning: Mixed carboxylic phosphoric anhydrides 3, formed from 3′-nucleotides 1 and amino acid N-carboxyanhydrides 2, undergo competing rearrangement to 2′-aminoacyl esters 4 and cyclization to 2′,3′-cyclic phosphates 5. The intramolecular aminoacyl transfer is faster than the cyclization despite the ease with which 2′,3′-cyclic phosphates are formed through any other form of phosphate activation. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
    Original languageEnglish
    Pages (from-to)6731-6734
    Number of pages3
    JournalAngewandte Chemie - International Edition
    Issue number41
    Publication statusPublished - 21 Oct 2005


    • Amino acids
    • Cyclization
    • N-carboxyanhydrides
    • Ribonucleotides
    • RNA


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