Experiences with functional magnetic resonance imaging at 1 tesla

A. P. Jones; D. G. Hughes; D. S. Brettle; L. Robinson; J. R. Sykes; Q. Aziz; S. Hamdy; D. G. Thompson; S. W G Derbyshire; A. C N Chen; A. K P Jones

Experiences with functional magnetic resonance imaging at 1 tesla

A. P. Jones, D. G. Hughes, D. S. Brettle, L. Robinson, J. R. Sykes, Q. Aziz, S. Hamdy, D. G. Thompson, S. W G Derbyshire, A. C N Chen, A. K P Jones

Research output: Contribution to journal › Article › peer-review

Abstract

Functional magnetic resonance imaging ((fMRI) has been performed on a standard 1 T system using a pulse sequence developed to utilize blood oxygen level dependent (BOLD) contrast and an off-line analysis routine using correlation techniques. The sequence and the data analysis routine have been validated by reproducing the conventional hand movement paradigm studies reported by numerous other workers. Our work has then been extended to investigate cerebral foci for a tonic pain stimulus and the cortical representation of oesophageal stimulation. Both these studies relate to paradigms where the expected BOLD signal is significantly less than that encountered for motor or visual cortex paradigms. The results show good agreement with other modalities (positron emission tomography, magnetoencephalography and cortical evoked potentials). Performing fMRI at 1 T is slightly controversial. However, our successful study of demanding paradigms, using a standard clinical 1 T imaging system, has important implications for many other users operating at this field strength.

Original language	English
Pages (from-to)	160-166
Number of pages	6
Journal	British Journal of Radiology
Volume	71
Publication status	Published - Feb 1998

Cite this

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title = "Experiences with functional magnetic resonance imaging at 1 tesla",

abstract = "Functional magnetic resonance imaging ((fMRI) has been performed on a standard 1 T system using a pulse sequence developed to utilize blood oxygen level dependent (BOLD) contrast and an off-line analysis routine using correlation techniques. The sequence and the data analysis routine have been validated by reproducing the conventional hand movement paradigm studies reported by numerous other workers. Our work has then been extended to investigate cerebral foci for a tonic pain stimulus and the cortical representation of oesophageal stimulation. Both these studies relate to paradigms where the expected BOLD signal is significantly less than that encountered for motor or visual cortex paradigms. The results show good agreement with other modalities (positron emission tomography, magnetoencephalography and cortical evoked potentials). Performing fMRI at 1 T is slightly controversial. However, our successful study of demanding paradigms, using a standard clinical 1 T imaging system, has important implications for many other users operating at this field strength.",

author = "Jones, {A. P.} and Hughes, {D. G.} and Brettle, {D. S.} and L. Robinson and Sykes, {J. R.} and Q. Aziz and S. Hamdy and Thompson, {D. G.} and Derbyshire, {S. W G} and Chen, {A. C N} and Jones, {A. K P}",

year = "1998",

month = feb,

language = "English",

volume = "71",

pages = "160--166",

journal = "British Journal of Radiology",

issn = "1748-880X",

publisher = "Oxford University Press",

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TY - JOUR

T1 - Experiences with functional magnetic resonance imaging at 1 tesla

AU - Jones, A. P.

AU - Hughes, D. G.

AU - Brettle, D. S.

AU - Robinson, L.

AU - Sykes, J. R.

AU - Aziz, Q.

AU - Hamdy, S.

AU - Thompson, D. G.

AU - Derbyshire, S. W G

AU - Chen, A. C N

AU - Jones, A. K P

PY - 1998/2

Y1 - 1998/2

N2 - Functional magnetic resonance imaging ((fMRI) has been performed on a standard 1 T system using a pulse sequence developed to utilize blood oxygen level dependent (BOLD) contrast and an off-line analysis routine using correlation techniques. The sequence and the data analysis routine have been validated by reproducing the conventional hand movement paradigm studies reported by numerous other workers. Our work has then been extended to investigate cerebral foci for a tonic pain stimulus and the cortical representation of oesophageal stimulation. Both these studies relate to paradigms where the expected BOLD signal is significantly less than that encountered for motor or visual cortex paradigms. The results show good agreement with other modalities (positron emission tomography, magnetoencephalography and cortical evoked potentials). Performing fMRI at 1 T is slightly controversial. However, our successful study of demanding paradigms, using a standard clinical 1 T imaging system, has important implications for many other users operating at this field strength.

AB - Functional magnetic resonance imaging ((fMRI) has been performed on a standard 1 T system using a pulse sequence developed to utilize blood oxygen level dependent (BOLD) contrast and an off-line analysis routine using correlation techniques. The sequence and the data analysis routine have been validated by reproducing the conventional hand movement paradigm studies reported by numerous other workers. Our work has then been extended to investigate cerebral foci for a tonic pain stimulus and the cortical representation of oesophageal stimulation. Both these studies relate to paradigms where the expected BOLD signal is significantly less than that encountered for motor or visual cortex paradigms. The results show good agreement with other modalities (positron emission tomography, magnetoencephalography and cortical evoked potentials). Performing fMRI at 1 T is slightly controversial. However, our successful study of demanding paradigms, using a standard clinical 1 T imaging system, has important implications for many other users operating at this field strength.

M3 - Article

C2 - 9579180

SN - 1748-880X

VL - 71

SP - 160

EP - 166

JO - British Journal of Radiology

JF - British Journal of Radiology

ER -

Experiences with functional magnetic resonance imaging at 1 tesla

Abstract

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