Experimental and Computational Evidence for the Mechanism of Intradiol Catechol Dioxygenation by Non‐Heme Iron (III) Complexes

Robin Jastrzebski, Matthew G Quesne, Bert M. Weckhuysen, Samuel De Visser, Pieter C.A. Bruijnincx

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    Abstract

    Catechol intradiol dioxygenation is a unique reaction catalyzed by iron-dependent enzymes and non-heme iron (III) complexes. The mechanism by which these systems activate dioxygen in this important metabolic process remains controversial. Using a combination of kinetic measurements and computational modelling of multiple iron (III) catecholato complexes, we have elucidated the catechol cleavage mechanism and show that oxygen binds the iron center by partial dissociation of the substrate from the iron
    Original languageEnglish
    Pages (from-to)15686–15691
    Number of pages5
    JournalChemistry: A European Journal
    Volume20
    Issue number48
    DOIs
    Publication statusPublished - 24 Nov 2014

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