Experimental approaches for the prevention of hematogenous metastasis

K Olden, S L White, S Mohla, S A Newton, Y Yasuda, D Bowen, M J Humphries

Research output: Contribution to journalArticlepeer-review


With improvements in surgical procedures and cure rates, the probable course of cancer for the majority of patients is now largely determined by metastasis rather than growth of the primary tumor itself. Thus, metastasis has received increasing attention over the past decade. These studies have led to the identification of several of the molecular events crucial for metastatic dissemination, information which is now being used to design therapeutic strategies to inhibit metastasis formation. Even though the molecular events involved in the dissemination of malignant disease are only partially known, several promising agents are now being tested for their capacity to limit the spread of cancer. A few clinical trials have shown benefit in prolonging survival and disease-free state, particularly when such therapy is employed on an adjuvant basis.

Original languageEnglish
Pages (from-to)83-91; discussion 95, 98-100
JournalOncology (Williston Park, N.Y.)
Issue number11
Publication statusPublished - Nov 1989


  • Antineoplastic Agents
  • Humans
  • Neoplasm Metastasis
  • Neoplastic Cells, Circulating


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