Experimental Models of SARS-CoV-2 Infection: Possible Platforms to Study COVID-19 Pathogenesis and Potential Treatments

Sareh Pandamooz, Benjamin Jurek, Carl-philipp Meinung, Zahra Baharvand, Alireza Sahebi Shahem-abadi, Silke Haerteis, Jaleel A. Miyan, James Downing, Mehdi Dianatpour, Afshin Borhani-haghighi, Mohammad Saied Salehi

Research output: Contribution to journalArticlepeer-review

Abstract

In December 2019, a novel coronavirus crossed species barriers to infect humans and was effectively transmitted from person to person, leading including vaccines and antiviral drugs that could prevent or limit the burden or transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health priority. It is thus of utmost importance to assess possible therapeutic strategies against SARS-CoV-2 using experimental models that recapitulate aspects of the human disease. Here, we review available models currently being developed and used to study SARS-CoV-2 infection and highlight their application to screen potential therapeutic approaches, including repurposed antiviral drugs and vaccines. Each identified model provides a valuable insight into SARS-CoV-2 cellular tropism, replication kinetics, and cell damage that could ultimately enhance understanding of SARS-CoV-2 pathogenesis and protective immunity.
Original languageEnglish
JournalAnnual Review of Pharmacology and Toxicology
Volume62
Issue number1
DOIs
Publication statusPublished - 19 Feb 2021

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