Exploitation of Mechanobiology for Cardiovascular Therapy

Winston Elliott, Amir Keshmiri, Wei Tan

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    Abstract

    The cardiovascular system is a dynamic, cyclically loaded, pressure-driven flow system that involves ongoing mechanical feedback loops directing cell response and extracellular matrix (ECM) remodeling, which sustain homeostasis of the system, guide adaptive remodeling of the vessel wall, and perpetuate disease progression. Mechanotransduction thus represents an important mechanism in determining vascular health and disease response, and can be exploited to provide improved vascular treatments. This chapter reviews research related to cardiovascular mechanobiology, focusing on two main topics: (i) arterial wall mechanics and mechanobiology, and their exploitation in understanding arterial disease progression and therapeutics; and (ii) the role of computational hemodynamics in cardiovascular mechanobiology, and its exploitation in vascular graft application.

    Original languageEnglish
    Title of host publicationMechanobiology
    Subtitle of host publicationExploitation for Medical Benefit
    PublisherJohn Wiley & Sons Ltd
    Pages373-400
    Number of pages28
    ISBN (Electronic)9781118966174
    ISBN (Print)9781118966143
    DOIs
    Publication statusPublished - 7 Nov 2016

    Keywords

    • Artery compliance
    • Computational flow dynamics
    • Fluid-structure interaction
    • Hemodynamics
    • Mechanical signaling
    • Vascular grafting
    • Vessel mechanics

    Research Beacons, Institutes and Platforms

    • Manchester Institute for Collaborative Research on Ageing

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