Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

Marnix H. Medema, Rainer Breitling, Roel Bovenberg, Eriko Takano

    Research output: Contribution to journalArticlepeer-review

    Abstract

    One of the most promising applications of synthetic biology is the biosynthesis of new drugs from secondary metabolites. Here, we survey a wide range of strategies that control the activity of biosynthetic modules in the cell in space and time, and illustrate how these strategies can be used to design efficient cellular synthetic production systems. Re-engineered versions of secondary metabolite biosynthetic pathways identified from any genomic sequence can then be inserted into these systems in a plug-and-play fashion. © 2011 Macmillan Publishers Limited. All rights reserved.
    Original languageEnglish
    Pages (from-to)131-137
    Number of pages6
    JournalNature Reviews Microbiology
    Volume9
    Issue number2
    DOIs
    Publication statusPublished - Feb 2011

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