Abstract
A tag removal-cyclisation sequence is described that is initiated by reduction using a Sm(ii) species and completed by a Sm(iii) Lewis acid that is formed in an earlier stage. Therefore, the reaction cascade utilises both oxidation states of a samarium reagent in discrete steps and allows access to privileged, pyrrolidinyl-spirooxindole scaffolds and analogues inspired by the anti-cancer natural product spirotryprostatin A. © The Royal Society of Chemistry 2011.
| Original language | English |
|---|---|
| Pages (from-to) | 5104-5108 |
| Number of pages | 4 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 9 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 21 Jul 2011 |
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CCDC 780381: Experimental Crystal Structure Determination
Coote, S. C. (Contributor), Quenum, S. (Contributor) & Procter, D. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011
DOI: 10.5517/ccv61ln, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccv61ln&sid=DataCite
Dataset
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CCDC 780380: Experimental Crystal Structure Determination
Coote, S. C. (Contributor), Quenum, S. (Contributor) & Procter, D. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011
DOI: 10.5517/ccv61km, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccv61km&sid=DataCite
Dataset
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CCDC 780379: Experimental Crystal Structure Determination
Coote, S. C. (Contributor), Quenum, S. (Contributor) & Procter, D. (Contributor), Cambridge Crystallographic Data Centre, 1 Jan 2011
DOI: 10.5517/ccv61jl, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/ccv61jl&sid=DataCite
Dataset