Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells.

Katherine A Hollywood; Catherine L Winder; Warwick B Dunn; Yun Xu; David Broadhurst; Christopher E M Griffiths; Roy Goodacre

doi:10.1039/c4mb00739e

Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells.

Katherine A Hollywood, Catherine L Winder, Warwick B Dunn, Yun Xu, David Broadhurst, Christopher E M Griffiths, Roy Goodacre

Research output: Contribution to journal › Article › peer-review

Abstract

Psoriasis is a common, immune-mediated inflammatory skin disease characterized by red, heavily scaled plaques. The disease affects over one million people in the UK and causes significant physical, psychological and societal impact. There is limited understanding regarding the exact pathogenesis of the disease although it is believed to be a consequence of genetic predisposition and environmental triggers. Treatments vary from topical therapies, such as dithranol, for disease of limited extent (

Original language	English
Journal	Molecular BioSystems
Volume	11
Issue number	8
DOIs	https://doi.org/10.1039/c4mb00739e
Publication status	Published - Aug 2015

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title = "Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells.",

abstract = "Psoriasis is a common, immune-mediated inflammatory skin disease characterized by red, heavily scaled plaques. The disease affects over one million people in the UK and causes significant physical, psychological and societal impact. There is limited understanding regarding the exact pathogenesis of the disease although it is believed to be a consequence of genetic predisposition and environmental triggers. Treatments vary from topical therapies, such as dithranol, for disease of limited extent (",

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AU - Winder, Catherine L

AU - Dunn, Warwick B

AU - Xu, Yun

AU - Broadhurst, David

AU - Griffiths, Christopher E M

AU - Goodacre, Roy

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AB - Psoriasis is a common, immune-mediated inflammatory skin disease characterized by red, heavily scaled plaques. The disease affects over one million people in the UK and causes significant physical, psychological and societal impact. There is limited understanding regarding the exact pathogenesis of the disease although it is believed to be a consequence of genetic predisposition and environmental triggers. Treatments vary from topical therapies, such as dithranol, for disease of limited extent (

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DO - 10.1039/c4mb00739e

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VL - 11

JO - Molecular BioSystems

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IS - 8

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Exploring the mode of action of dithranol therapy for psoriasis: a metabolomic analysis using HaCaT cells.

Abstract

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