Exploring the pharmacological properties of insect nicotinic acetylcholine receptors

Steeve H. Thany; Guy Lenaers; Valérie Raymond-Delpech; David B. Sattelle; Bruno Lapied

doi:10.1016/j.tips.2006.11.006

Exploring the pharmacological properties of insect nicotinic acetylcholine receptors

Steeve H. Thany, Guy Lenaers, Valérie Raymond-Delpech, David B. Sattelle, Bruno Lapied

Research output: Contribution to journal › Article › peer-review

Abstract

Insect nicotinic acetylcholine (nACh) receptors are molecular targets of insecticides such as neonicotinoids that are used to control disease-carrying insects and agricultural pests. To date, several insect nACh receptor subunits have been identified, indicating different nACh receptor subtypes and pharmacological profiles. Because of the difficulty in expressing functional insect nACh receptors in heterologous systems, new research tools are needed. Studies on insects resistant to the insecticide imidacloprid and on laboratory-generated hybrid and chimaeric nACh receptors in vitro have provided information about the molecular basis of receptor diversity, neonicotinoid resistance and selectivity. Additionally, recent results indicate that the sensitivity of insect nACh receptors to imidacloprid can be modulated by intracellular phosphorylation mechanisms, which offers a new approach to studying insect nACh receptor pharmacology. © 2006 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	14-22
Number of pages	8
Journal	Trends in pharmacological sciences
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/j.tips.2006.11.006
Publication status	Published - Jan 2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tips.2006.11.006

Cite this

@article{59a9a0783b5e49aaa1009407fb324df8,

title = "Exploring the pharmacological properties of insect nicotinic acetylcholine receptors",

abstract = "Insect nicotinic acetylcholine (nACh) receptors are molecular targets of insecticides such as neonicotinoids that are used to control disease-carrying insects and agricultural pests. To date, several insect nACh receptor subunits have been identified, indicating different nACh receptor subtypes and pharmacological profiles. Because of the difficulty in expressing functional insect nACh receptors in heterologous systems, new research tools are needed. Studies on insects resistant to the insecticide imidacloprid and on laboratory-generated hybrid and chimaeric nACh receptors in vitro have provided information about the molecular basis of receptor diversity, neonicotinoid resistance and selectivity. Additionally, recent results indicate that the sensitivity of insect nACh receptors to imidacloprid can be modulated by intracellular phosphorylation mechanisms, which offers a new approach to studying insect nACh receptor pharmacology. {\textcopyright} 2006 Elsevier Ltd. All rights reserved.",

author = "Thany, {Steeve H.} and Guy Lenaers and Val{\'e}rie Raymond-Delpech and Sattelle, {David B.} and Bruno Lapied",

year = "2007",

month = jan,

doi = "10.1016/j.tips.2006.11.006",

language = "English",

volume = "28",

pages = "14--22",

journal = "Trends in pharmacological sciences",

issn = "1873-3735",

publisher = "Elsevier BV",

number = "1",

}

TY - JOUR

T1 - Exploring the pharmacological properties of insect nicotinic acetylcholine receptors

AU - Thany, Steeve H.

AU - Lenaers, Guy

AU - Raymond-Delpech, Valérie

AU - Sattelle, David B.

AU - Lapied, Bruno

PY - 2007/1

Y1 - 2007/1

N2 - Insect nicotinic acetylcholine (nACh) receptors are molecular targets of insecticides such as neonicotinoids that are used to control disease-carrying insects and agricultural pests. To date, several insect nACh receptor subunits have been identified, indicating different nACh receptor subtypes and pharmacological profiles. Because of the difficulty in expressing functional insect nACh receptors in heterologous systems, new research tools are needed. Studies on insects resistant to the insecticide imidacloprid and on laboratory-generated hybrid and chimaeric nACh receptors in vitro have provided information about the molecular basis of receptor diversity, neonicotinoid resistance and selectivity. Additionally, recent results indicate that the sensitivity of insect nACh receptors to imidacloprid can be modulated by intracellular phosphorylation mechanisms, which offers a new approach to studying insect nACh receptor pharmacology. © 2006 Elsevier Ltd. All rights reserved.

AB - Insect nicotinic acetylcholine (nACh) receptors are molecular targets of insecticides such as neonicotinoids that are used to control disease-carrying insects and agricultural pests. To date, several insect nACh receptor subunits have been identified, indicating different nACh receptor subtypes and pharmacological profiles. Because of the difficulty in expressing functional insect nACh receptors in heterologous systems, new research tools are needed. Studies on insects resistant to the insecticide imidacloprid and on laboratory-generated hybrid and chimaeric nACh receptors in vitro have provided information about the molecular basis of receptor diversity, neonicotinoid resistance and selectivity. Additionally, recent results indicate that the sensitivity of insect nACh receptors to imidacloprid can be modulated by intracellular phosphorylation mechanisms, which offers a new approach to studying insect nACh receptor pharmacology. © 2006 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.tips.2006.11.006

DO - 10.1016/j.tips.2006.11.006

M3 - Article

C2 - 17156860

SN - 1873-3735

VL - 28

SP - 14

EP - 22

JO - Trends in pharmacological sciences

JF - Trends in pharmacological sciences

IS - 1

ER -

Exploring the pharmacological properties of insect nicotinic acetylcholine receptors

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this